Safety of Contrast Material Use in Children

Bruno P. Soares, Maarten H. Lequin, Thierry A.G.M. Huisman

Research output: Contribution to journalReview articlepeer-review


Iodinated and gadolinium-based contrast materials have excellent safety profiles for use in pediatric computed tomography and MR imaging. The rate of acute adverse reactions and contrast-induced nephropathy is lower than in adults. The relationship between nephrogenic systemic fibrosis and gadolinium administration is well established and only a small number of children suffer from this debilitating disorder. The recent finding of gadolinium deposition in the brain of patients with normal renal function has renewed concerns regarding its long-term toxicity. The necessity of gadolinium-based contrast agent use in children should be considered carefully for each examination, and more stable macrocyclic agents should be the primary choice.

Original languageEnglish (US)
Pages (from-to)779-785
Number of pages7
JournalMagnetic Resonance Imaging Clinics of North America
Issue number4
StatePublished - Nov 2017


  • Computed tomography
  • Contrast material
  • Gadolinium
  • Magnetic resonance imaging
  • Nephrogenic systemic fibrosis
  • Pediatric imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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