Safety of Contrast Material Use in Children

Bruno Soares, Maarten H. Lequin, Thierry A.G.M. Huisman

Research output: Contribution to journalArticlepeer-review


Iodinated and gadolinium-based contrast materials have excellent safety profiles for use in pediatric computed tomography and MR imaging. The rate of acute adverse reactions and contrast-induced nephropathy is lower than in adults. The relationship between nephrogenic systemic fibrosis and gadolinium administration is well established and only a small number of children suffer from this debilitating disorder. The recent finding of gadolinium deposition in the brain of patients with normal renal function has renewed concerns regarding its long-term toxicity. The necessity of gadolinium-based contrast agent use in children should be considered carefully for each examination, and more stable macrocyclic agents should be the primary choice.

Original languageEnglish (US)
JournalMagnetic Resonance Imaging Clinics of North America
StateAccepted/In press - 2017


  • Computed tomography
  • Contrast material
  • Gadolinium
  • Magnetic resonance imaging
  • Nephrogenic systemic fibrosis
  • Pediatric imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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