Safety of and compliance with community-based ivermectin therapy

M. Pacqué, Beatriz Munoz, H. R. Taylor, Z. Dukuly, B. M. Greene, A. T. White

Research output: Contribution to journalArticle

Abstract

In a study of the safety, acceptability, and efficacy of ivermectin for community-based mass treatment of onchocerciasis, the drug was issued twice, one year apart, to the population of a rubber plantation (14000 people) in Liberia, where over 80% of the adults have Onchocerca volvulusinfection. The plantation microfilarial load in a sample of adults was reduced by 86% 6 months after initial treatment and by 78% after 1 year. Compliance was 97% with each round of treatment. After the initial treatment of 7699 people, 101 (1·3%) had moderate adverse reactions. After re-treatment only 37 (0·5%) people had moderate adverse reactions. No ivermectin-related death or severe adverse reactions occurred. The data show that community-based treatment with ivermectin is well accepted and effective in reducing microfilarial loads. Ivermectin is likely to provide the first realistic means of chemotherapy-based control of onchocerciasis on a mass scale.

Original languageEnglish (US)
Pages (from-to)1377-1380
Number of pages4
JournalThe Lancet
Volume335
Issue number8702
DOIs
StatePublished - Jun 9 1990

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Ivermectin
Safety
Onchocerciasis
Therapeutics
Liberia
Onchocerca
Rubber
Compliance
Drug Therapy
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pacqué, M., Munoz, B., Taylor, H. R., Dukuly, Z., Greene, B. M., & White, A. T. (1990). Safety of and compliance with community-based ivermectin therapy. The Lancet, 335(8702), 1377-1380. https://doi.org/10.1016/0140-6736(90)91253-7

Safety of and compliance with community-based ivermectin therapy. / Pacqué, M.; Munoz, Beatriz; Taylor, H. R.; Dukuly, Z.; Greene, B. M.; White, A. T.

In: The Lancet, Vol. 335, No. 8702, 09.06.1990, p. 1377-1380.

Research output: Contribution to journalArticle

Pacqué, M, Munoz, B, Taylor, HR, Dukuly, Z, Greene, BM & White, AT 1990, 'Safety of and compliance with community-based ivermectin therapy', The Lancet, vol. 335, no. 8702, pp. 1377-1380. https://doi.org/10.1016/0140-6736(90)91253-7
Pacqué M, Munoz B, Taylor HR, Dukuly Z, Greene BM, White AT. Safety of and compliance with community-based ivermectin therapy. The Lancet. 1990 Jun 9;335(8702):1377-1380. https://doi.org/10.1016/0140-6736(90)91253-7
Pacqué, M. ; Munoz, Beatriz ; Taylor, H. R. ; Dukuly, Z. ; Greene, B. M. ; White, A. T. / Safety of and compliance with community-based ivermectin therapy. In: The Lancet. 1990 ; Vol. 335, No. 8702. pp. 1377-1380.
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