Safety and immunogenicity of multiple conventional immunizations administered during early HIV infection

Twenty-one asymptomatic adults who had recently received multiple polysaccharide, live viral, and protein-derived vaccines were identified as being infected with human immunodeficiency virus (HIV). The mean subject age was 24 years trange 18;33; 20 of 21 (95) were male. The mean T4 count was 523 mm with a mean T1.T8 ratio of 0.6. Serologic responses to immunization with meningococcus group C. adenovirus types 4 and 7, tetanus, and dephteria were evaluated for the HIV seropositive subjects and were compared with the responses of similarly vaccinated age, sex, and race-matched HIV-seronegative controls. Significantly fewer (p = 0.03) HIV subjects responded to meningococcus C (bactericidal antibody) and adenovirus 4 (neutralizing antibody) vaccines that did normals; the HIV-infected subjects who Booster responses of HIV subjects to tetanus and diphthera were comparable to those of normals. HIV-infected vaccine nonresponders did not differ from HIV-infected tesponders in total white blood cell. T1, T4, T8, total serum IgG, or delayed-type hypersensitivity skin test reactivity. All HIV subjects had negative cultures for live vaccine viruses (rubella, measles, adenovirus, and poliovirus). Postimmunization, no clinically apparent adverse reactions to vaceination were detected.