Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

Mark L. Bagarazzi, Jean D. Boyer, Kenneth E. Ugen, M. Ali Javadian, Michael Anand Chattergoon, Ami Shah, Mosi Bennett, Richard Ciccarelli, Richard Carrano, Leslie Coney, David B. Weiner

Research output: Contribution to journalArticle

Abstract

A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.

Original languageEnglish (US)
Pages (from-to)1836-1841
Number of pages6
JournalVaccine
Volume16
Issue number19
DOIs
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Pan troglodytes
Human immunodeficiency virus 1
HIV-1
Vaccines
immune response
vaccines
Safety
DNA
Humoral Immunity
humoral immunity
Cellular Immunity
cell-mediated immunity
Immunization
plasmids
immunization
Plasmids
HIV

Keywords

  • Antibody
  • CTL
  • Flow cytometry
  • Gene
  • Immunization
  • Lymphocyte proliferation
  • Mucosal
  • Plasmid
  • Primate

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Bagarazzi, M. L., Boyer, J. D., Ugen, K. E., Javadian, M. A., Chattergoon, M. A., Shah, A., ... Weiner, D. B. (1998). Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees. Vaccine, 16(19), 1836-1841. https://doi.org/10.1016/S0264-410X(98)00178-9

Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees. / Bagarazzi, Mark L.; Boyer, Jean D.; Ugen, Kenneth E.; Javadian, M. Ali; Chattergoon, Michael Anand; Shah, Ami; Bennett, Mosi; Ciccarelli, Richard; Carrano, Richard; Coney, Leslie; Weiner, David B.

In: Vaccine, Vol. 16, No. 19, 11.1998, p. 1836-1841.

Research output: Contribution to journalArticle

Bagarazzi, ML, Boyer, JD, Ugen, KE, Javadian, MA, Chattergoon, MA, Shah, A, Bennett, M, Ciccarelli, R, Carrano, R, Coney, L & Weiner, DB 1998, 'Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees', Vaccine, vol. 16, no. 19, pp. 1836-1841. https://doi.org/10.1016/S0264-410X(98)00178-9
Bagarazzi ML, Boyer JD, Ugen KE, Javadian MA, Chattergoon MA, Shah A et al. Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees. Vaccine. 1998 Nov;16(19):1836-1841. https://doi.org/10.1016/S0264-410X(98)00178-9
Bagarazzi, Mark L. ; Boyer, Jean D. ; Ugen, Kenneth E. ; Javadian, M. Ali ; Chattergoon, Michael Anand ; Shah, Ami ; Bennett, Mosi ; Ciccarelli, Richard ; Carrano, Richard ; Coney, Leslie ; Weiner, David B. / Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees. In: Vaccine. 1998 ; Vol. 16, No. 19. pp. 1836-1841.
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