Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

Mark L. Bagarazzi; Jean D. Boyer; Kenneth E. Ugen; M. Ali Javadian; Michael Chattergoon; Ami Shah; Mosi Bennett; Richard Ciccarelli; Richard Carrano; Leslie Coney; David B. Weiner

doi:10.1016/S0264-410X(98)00178-9

Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

Mark L. Bagarazzi, Jean D. Boyer, Kenneth E. Ugen, M. Ali Javadian, Michael Chattergoon, Ami Shah, Mosi Bennett, Richard Ciccarelli, Richard Carrano, Leslie Coney, David B. Weiner

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.

Original language	English (US)
Pages (from-to)	1836-1841
Number of pages	6
Journal	Vaccine
Volume	16
Issue number	19
DOIs	https://doi.org/10.1016/S0264-410X(98)00178-9
State	Published - Nov 1998
Externally published	Yes

Keywords

Antibody
CTL
Flow cytometry
Gene
Immunization
Lymphocyte proliferation
Mucosal
Plasmid
Primate

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(98)00178-9

Cite this

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title = "Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees",

abstract = "A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.",

keywords = "Antibody, CTL, Flow cytometry, Gene, Immunization, Lymphocyte proliferation, Mucosal, Plasmid, Primate",

author = "Bagarazzi, {Mark L.} and Boyer, {Jean D.} and Ugen, {Kenneth E.} and Javadian, {M. Ali} and Michael Chattergoon and Ami Shah and Mosi Bennett and Richard Ciccarelli and Richard Carrano and Leslie Coney and Weiner, {David B.}",

note = "Funding Information: This work was supportedi n part, by grants to DBW from the National Institutes of Health, including a SPIRAT grant and MLB through an NIAID Mentored Clinical ScientistD evelopmentA ward.",

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doi = "10.1016/S0264-410X(98)00178-9",

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T1 - Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

AU - Bagarazzi, Mark L.

AU - Boyer, Jean D.

AU - Ugen, Kenneth E.

AU - Javadian, M. Ali

AU - Chattergoon, Michael

AU - Shah, Ami

AU - Bennett, Mosi

AU - Ciccarelli, Richard

AU - Carrano, Richard

AU - Coney, Leslie

AU - Weiner, David B.

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PY - 1998/11

Y1 - 1998/11

N2 - A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.

AB - A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.

KW - Antibody

KW - CTL

KW - Flow cytometry

KW - Gene

KW - Immunization

KW - Lymphocyte proliferation

KW - Mucosal

KW - Plasmid

KW - Primate

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ER -

Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

Abstract

Keywords

ASJC Scopus subject areas

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