Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

Mark L. Bagarazzi, Jean D. Boyer, Kenneth E. Ugen, M. Ali Javadian, Michael Anand Chattergoon, Ami Shah, Mosi Bennett, Richard Ciccarelli, Richard Carrano, Leslie Coney, David B. Weiner

Research output: Contribution to journalArticle

Abstract

A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.

Original languageEnglish (US)
Pages (from-to)1836-1841
Number of pages6
JournalVaccine
Volume16
Issue number19
DOIs
Publication statusPublished - Nov 1998
Externally publishedYes

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Keywords

  • Antibody
  • CTL
  • Flow cytometry
  • Gene
  • Immunization
  • Lymphocyte proliferation
  • Mucosal
  • Plasmid
  • Primate

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Bagarazzi, M. L., Boyer, J. D., Ugen, K. E., Javadian, M. A., Chattergoon, M. A., Shah, A., ... Weiner, D. B. (1998). Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees. Vaccine, 16(19), 1836-1841. https://doi.org/10.1016/S0264-410X(98)00178-9