Safety and efficacy of sonographically guided random core biopsy for diffuse liver disease

L. N. Nazarian, R. I. Feld, S. K. Herrine, D. Webner, A. S. Lev-Toaff, Pamela Johnson, L. A. Storey, L. Needleman

Research output: Contribution to journalArticle

Abstract

Sonographic guidance is commonly used in the biopsy of focal hepatic lesions, but biopsy for diffuse disease is often non-image-guided. We evaluated the safety and efficacy of real-time sonographically guided random core biopsy in the assessment of diffuse liver disease in 210 patients. The two most common indications for biopsy were viral hepatitis (in 113 patients) and elevated liver function test results of unknown cause (in 54 patients). Ultrasonography and pathology reports were reviewed retrospectively to determine number of needle passes and final diagnoses. Adequate tissue was obtained in all 210 patients, with 259 of 269 (96%) passes having been successful. Specimens were submitted for light microscopy and other tests as indicated. No difference in success rates was found for right and left lobe biopsies. No major complications occurred. Minor complications occurred in 10 of 210 (4.8%) patients and were self-limited. Sonographically guided core liver biopsy is a safe and effective method for the diagnosis of liver disease.

Original languageEnglish (US)
Pages (from-to)537-541
Number of pages5
JournalJournal of Ultrasound in Medicine
Volume19
Issue number8
StatePublished - 2000
Externally publishedYes

Fingerprint

liver
Liver Diseases
safety
Biopsy
Safety
hepatitis
pathology
needles
lobes
Liver
Liver Function Tests
lesions
indication
Hepatitis
Needles
Microscopy
Ultrasonography
microscopy
Pathology
causes

Keywords

  • Biopsy, ultrasonographic guidance
  • Hepatitis, viral
  • Liver, biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Acoustics and Ultrasonics
  • Radiological and Ultrasound Technology

Cite this

Nazarian, L. N., Feld, R. I., Herrine, S. K., Webner, D., Lev-Toaff, A. S., Johnson, P., ... Needleman, L. (2000). Safety and efficacy of sonographically guided random core biopsy for diffuse liver disease. Journal of Ultrasound in Medicine, 19(8), 537-541.

Safety and efficacy of sonographically guided random core biopsy for diffuse liver disease. / Nazarian, L. N.; Feld, R. I.; Herrine, S. K.; Webner, D.; Lev-Toaff, A. S.; Johnson, Pamela; Storey, L. A.; Needleman, L.

In: Journal of Ultrasound in Medicine, Vol. 19, No. 8, 2000, p. 537-541.

Research output: Contribution to journalArticle

Nazarian, LN, Feld, RI, Herrine, SK, Webner, D, Lev-Toaff, AS, Johnson, P, Storey, LA & Needleman, L 2000, 'Safety and efficacy of sonographically guided random core biopsy for diffuse liver disease', Journal of Ultrasound in Medicine, vol. 19, no. 8, pp. 537-541.
Nazarian, L. N. ; Feld, R. I. ; Herrine, S. K. ; Webner, D. ; Lev-Toaff, A. S. ; Johnson, Pamela ; Storey, L. A. ; Needleman, L. / Safety and efficacy of sonographically guided random core biopsy for diffuse liver disease. In: Journal of Ultrasound in Medicine. 2000 ; Vol. 19, No. 8. pp. 537-541.
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