Safety and Efficacy of High-Dose Interleukin-2 Therapy in Patients With Brain Metastases

Lisa M. Guirguis, James C. Yang, Donald E. White, Seth M. Steinberg, David J. Liewehr, Steven A. Rosenberg, Douglas J. Schwartzentruber

Research output: Contribution to journalArticle

Abstract

The authors determined the safety and efficacy of recombinant high-dose interleukin-2 administration in patients with brain metastases. This retrospective review included 1,069 patients with metastatic melanoma or renal cell carcinoma who received high-dose interleukin-2 alone or in combination with other immunotherapy or chemotherapy from July 1985-July 2000. All patients were evaluated for both toxicity and response. Only the first exposure to interleukin-2 was considered. Parameters evaluated among the groups included toxicity profiles, reasons for stopping treatment, number of interleukin-2 doses per cycle, and response to therapy. Three patient groups were compared. Group 1 (n = 27) comprised patients with previously treated brain metastases (surgery or radiation), group 2 (n = 37) comprised patients with untreated brain metastases, and group 3 (n = 1,005) comprised patients without brain metastases. For most comparisons between patients with brain metastases and those without, no significant differences were noted in toxicity profiles or reasons for stopping interleukin-2 therapy. Patients with previously treated brain metastases received fewer interleukin-2 doses per cycle (median, 6.5) than patients with previously untreated brain metastases (median, 7.5) or patients without brain metastases (median, 7.5). Patients with previously treated brain metastases demonstrated an 18.5% overall clinical response to interleukin-2 treatment. However, patients with evaluable (previously untreated) brain metastases had an overall 5.6% response rate, which was less than the 19.8% response rate of patients without brain metastases. Two of thirty-six patients with evaluable brain metastases demonstrated objective regression of intracranial and extracranial disease after receiving interleukin-2. Carefully selected patients with brain metastases can safely receive high-dose interleukin-2, and some can experience a response to treatment at intracranial and extracranial disease sites.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalJournal of Immunotherapy
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2002

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Keywords

  • Brain metastases
  • Interleukin-2
  • Melanoma
  • Safety

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

Cite this

Guirguis, L. M., Yang, J. C., White, D. E., Steinberg, S. M., Liewehr, D. J., Rosenberg, S. A., & Schwartzentruber, D. J. (2002). Safety and Efficacy of High-Dose Interleukin-2 Therapy in Patients With Brain Metastases. Journal of Immunotherapy, 25(1), 82-87. https://doi.org/10.1097/00002371-200201000-00009