Safety and efficacy of bupropion combined with bromocriptine for treatment of cocaine dependence

Ivan D. Montoya, Kenzie L. Preston, Edward J. Cone, Richard Rothman, David A. Gorelick

Research output: Contribution to journalArticle

Abstract

Bupropion and bromocriptine have been used separately for treatment of cocaine dependence. This 8-week, open-label study tested the combination of bupropion and bromocriptine with the goal of obtaining an enhanced therapeutic effect with fewer side effects. Thirteen cocaine-dependent (DSM-III-R criteria) subjects received bupropion (≤ 300 mg) plus bromocriptine (≤ 7.5 mg) daily, in addition to weekly individual standardized counseling. No serious adverse events were reported. There were significant (P < 0.01) reductions between pretreatment and post-treatment for patients' self-reported weekly grams used, money spent on cocaine, and Beck Depression Inventory score; however, there were no significant changes in the results of urine toxicology tests for cocaine (qualitative and quantitative) or self-reported drug craving. These results suggest that the combination of bupropion and bromocriptine may be safe and have some efficacy in treatment of cocaine dependence.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalAmerican Journal on Addictions
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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