TY - JOUR
T1 - Sacropelvic resection for recurrent anorectal cancer
T2 - A multidisciplinary approach
AU - Weber, Kristy L.
AU - Nelson, Heidi
AU - Gunderson, Leonard L.
AU - Sim, Franklin H.
PY - 2000
Y1 - 2000
N2 - A multimodal approach including preoperative external beam radiation, surgical resection, and intraoperative electron radiation was used in 23 patients with locally advanced anal or recurrent rectal cancers involving the sacrum. The proximal extent of complete sacral resection was S2 in three patients, S3 in 12 patients, S4 in two patients, and S5 in one patient. The tumor was confined to the anterior sacral cortex in five patients. The resection was marginal in 10, contaminated marginal in 11, and intralesional in two patients. At 19 to 54 months of followup, five patients are alive without evidence of disease and four are alive with disease. Twelve patients died of their disease, and two died of other causes. There was a mean survival of 32.9 months for the patients who were alive at followup. Kaplan- Meier survival for all patients was 82% at 1 year and 73% at 2 years, with death of disease as an endpoint. Thirteen (57%) patients had another local recurrence develop at a mean of 17.2 months. Eight (35%) patients had metastatic disease develop at a mean of 16.3 months. Proper patient selection is important in ensuring a favorable outcome from this aggressive surgery.
AB - A multimodal approach including preoperative external beam radiation, surgical resection, and intraoperative electron radiation was used in 23 patients with locally advanced anal or recurrent rectal cancers involving the sacrum. The proximal extent of complete sacral resection was S2 in three patients, S3 in 12 patients, S4 in two patients, and S5 in one patient. The tumor was confined to the anterior sacral cortex in five patients. The resection was marginal in 10, contaminated marginal in 11, and intralesional in two patients. At 19 to 54 months of followup, five patients are alive without evidence of disease and four are alive with disease. Twelve patients died of their disease, and two died of other causes. There was a mean survival of 32.9 months for the patients who were alive at followup. Kaplan- Meier survival for all patients was 82% at 1 year and 73% at 2 years, with death of disease as an endpoint. Thirteen (57%) patients had another local recurrence develop at a mean of 17.2 months. Eight (35%) patients had metastatic disease develop at a mean of 16.3 months. Proper patient selection is important in ensuring a favorable outcome from this aggressive surgery.
UR - http://www.scopus.com/inward/record.url?scp=0034064684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034064684&partnerID=8YFLogxK
U2 - 10.1097/00003086-200003000-00025
DO - 10.1097/00003086-200003000-00025
M3 - Article
C2 - 10738432
AN - SCOPUS:0034064684
SN - 0009-921X
VL - 372
SP - 231
EP - 240
JO - Clinical orthopaedics and related research
JF - Clinical orthopaedics and related research
ER -