Saccharomyces cerevisiae polymerase ζ functions in mitochondria

Hengshan Zhang, Aditi Chatterjee, Keshav K. Singh

Research output: Contribution to journalArticle

Abstract

The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase ζ and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase ζ and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase ζ and Rev1 proteins function in the mitochondria.

Original languageEnglish (US)
Pages (from-to)2683-2688
Number of pages6
JournalGenetics
Volume172
Issue number4
DOIs
StatePublished - Apr 2006

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DNA-Directed DNA Polymerase
Mitochondrial DNA
Saccharomyces cerevisiae
Mitochondria
Saccharomycetales
Point Mutation
Mutagenesis
Proteins

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Saccharomyces cerevisiae polymerase ζ functions in mitochondria. / Zhang, Hengshan; Chatterjee, Aditi; Singh, Keshav K.

In: Genetics, Vol. 172, No. 4, 04.2006, p. 2683-2688.

Research output: Contribution to journalArticle

Zhang, H, Chatterjee, A & Singh, KK 2006, 'Saccharomyces cerevisiae polymerase ζ functions in mitochondria', Genetics, vol. 172, no. 4, pp. 2683-2688. https://doi.org/10.1534/genetics.105.051029
Zhang, Hengshan ; Chatterjee, Aditi ; Singh, Keshav K. / Saccharomyces cerevisiae polymerase ζ functions in mitochondria. In: Genetics. 2006 ; Vol. 172, No. 4. pp. 2683-2688.
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