Abstract
The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase ζ and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase ζ and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase ζ and Rev1 proteins function in the mitochondria.
Original language | English (US) |
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Pages (from-to) | 2683-2688 |
Number of pages | 6 |
Journal | Genetics |
Volume | 172 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics