Saccadic burst cell membrane dysfunction is responsible for saccadic oscillations

Aasef G. Shaikh, Stefano Ramat, Lance M. Optican, Kenichiro Miura, R. John Leigh, David S. Zee

Research output: Contribution to journalReview articlepeer-review

Abstract

Saccadic oscillations threaten clear vision by causing image motion on the retina. They are either purely horizontal (ocular flutter) or multidimensional (opsoclonus). We propose that ion channel dysfunction in the burst cell membrane is the underlying abnormality. We have tested this hypothesis by simulating a neuromimetic computational model of the burst neurons. This biologically realistic model mimics the physiologic properties and anatomic connections in the brainstem saccade generator. A rebound firing after sustained inhibition, called post-inhibitory rebound (PIR), and reciprocal inhibition between premotor saccadic burst neurons are the key features of this conceptual scheme. PIR and reciprocal inhibition make the circuits that generate the saccadic burst inherently unstable and can lead to oscillations unless stabilized by external inhibition. Our simulations suggest that alterations in membrane properties that lead to an increase in PIR, a reduction in external glycinergic inhibition, or both can cause saccadic oscillations.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalJournal of Neuro-Ophthalmology
Volume28
Issue number4
DOIs
StatePublished - Dec 2008

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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