SA11 rotavirus is specifically inhibited by an acetylated sialic acid

Rodney E. Willoughby, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Bovine salivary mucin (BSM) inhibits rotavirus replication in vitro and in vivo. The inhibitory effect of BSM in vitro is abolished by Arthrobacter ureafaciens neuraminidase but not by Clostridia perfringens neuraminidase; it is abolished by mild base deacetylation but not by influenza C acetylesterase. The data suggest that SA11 rotavirus binds to a specific sialic acid structure on BSM different from the sialic acids recognized by other viruses.

Original languageEnglish (US)
Pages (from-to)116-119
Number of pages4
JournalJournal of Infectious Diseases
Volume161
Issue number1
StatePublished - Jan 1990

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Rotavirus
N-Acetylneuraminic Acid
Mucins
Neuraminidase
Acetylesterase
Sialic Acids
Arthrobacter
Clostridium perfringens
Human Influenza
Viruses
In Vitro Techniques

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

SA11 rotavirus is specifically inhibited by an acetylated sialic acid. / Willoughby, Rodney E.; Yolken, Robert H.

In: Journal of Infectious Diseases, Vol. 161, No. 1, 01.1990, p. 116-119.

Research output: Contribution to journalArticle

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