SA11 rotavirus is specifically inhibited by an acetylated sialic acid

Rodney E. Willoughby, Robert H. Yolken

Research output: Contribution to journalArticlepeer-review

Abstract

Bovine salivary mucin (BSM) inhibits rotavirus replication in vitro and in vivo. The inhibitory effect of BSM in vitro is abolished by Arthrobacter ureafaciens neuraminidase but not by Clostridia perfringens neuraminidase; it is abolished by mild base deacetylation but not by influenza C acetylesterase. The data suggest that SA11 rotavirus binds to a specific sialic acid structure on BSM different from the sialic acids recognized by other viruses.

Original languageEnglish (US)
Pages (from-to)116-119
Number of pages4
JournalJournal of Infectious Diseases
Volume161
Issue number1
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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