TY - JOUR
T1 - S100A4 expression is a prognostic indicator in small intestine adenocarcinoma
AU - Roh, Jin
AU - Knight, Spencer
AU - Chung, Joon Yong
AU - Eo, Soo Heang
AU - Goggins, Michael
AU - Kim, Jihoon
AU - Cho, Hyung Jun
AU - Yu, Eunsil
AU - Hong, Seung Mo
PY - 2014/3
Y1 - 2014/3
N2 - Aims Due to the rarity of small intestine adenocarcinoma (SIAC), estimating the prognosis for patients with surgically resected SIAC is difficult. Overexpression of S100A4 has been linked to worse patient survival in several malignant neoplasms, but its significance in SIAC has not been determined. Methods S100A4 protein expression was assessed in 197 surgically resected SIAC cases and compared with clinicopathological factors, including patient survival. Results A progressive increase in S100A4 labelling was observed in normal intestinal epithelium, adenoma and adenocarcinoma (p<0.001), and 50 SIAC cases (26.2%) showed strong S100A4 expression. Patients with SIAC with strong S100A4 expression had a higher pT classification ( p=0.05), as well as increased lymph node metastasis (p=0.009) and perineural invasion (p=0.002). Patients with SIAC with strong S100A4 expression had significantly worse survival (median survival, 21 months) than those with weak/no S100A4 expression (42.5 months) by univariable ( p=0.04) and multivariable ( p=0.01) analyses. Conclusions S100A4 overexpression is observed in a subset of SIACs, is associated with advanced disease and can be used as a prognostic indicator of poor prognosis in patients with SIAC.
AB - Aims Due to the rarity of small intestine adenocarcinoma (SIAC), estimating the prognosis for patients with surgically resected SIAC is difficult. Overexpression of S100A4 has been linked to worse patient survival in several malignant neoplasms, but its significance in SIAC has not been determined. Methods S100A4 protein expression was assessed in 197 surgically resected SIAC cases and compared with clinicopathological factors, including patient survival. Results A progressive increase in S100A4 labelling was observed in normal intestinal epithelium, adenoma and adenocarcinoma (p<0.001), and 50 SIAC cases (26.2%) showed strong S100A4 expression. Patients with SIAC with strong S100A4 expression had a higher pT classification ( p=0.05), as well as increased lymph node metastasis (p=0.009) and perineural invasion (p=0.002). Patients with SIAC with strong S100A4 expression had significantly worse survival (median survival, 21 months) than those with weak/no S100A4 expression (42.5 months) by univariable ( p=0.04) and multivariable ( p=0.01) analyses. Conclusions S100A4 overexpression is observed in a subset of SIACs, is associated with advanced disease and can be used as a prognostic indicator of poor prognosis in patients with SIAC.
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U2 - 10.1136/jclinpath-2013-201883
DO - 10.1136/jclinpath-2013-201883
M3 - Article
C2 - 24062356
AN - SCOPUS:84894253123
SN - 0021-9746
VL - 67
SP - 216
EP - 221
JO - Molecular pathology : MP
JF - Molecular pathology : MP
IS - 3
ER -