Abstract
S100β is a calcium-binding protein elevated in Down's syndrome and Alzheimer's disease. Previous studies have demonstrated that S100β is trophic for several neuronal populations. We tested the influence of S100β on hippocampal neurons. The initial response included a rapid increase in [Ca2+]i similar to that elicited by S100β in other populations. S100β also substantially decreased cell death and loss of mitochondrial function resulting from glucose deprivation. Therefore, S100β exerts a neuroprotective influence on CNS neurons, suggesting that its elevation in neurological disorders may be a compensatory response.
Original language | English (US) |
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Pages (from-to) | 167-170 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 677 |
Issue number | 1 |
DOIs | |
State | Published - Apr 17 1995 |
Externally published | Yes |
Keywords
- Calcium
- Glucose
- Hippocampus
- Mitochondria
- Neurotrophic
- S100
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- General Neuroscience