TY - JOUR
T1 - S-Nitrosylation
T2 - Specificity, occupancy, and interaction with other post-translational modifications
AU - Evangelista, Alicia M.
AU - Kohr, Mark J.
AU - Murphy, Elizabeth
PY - 2013/10/10
Y1 - 2013/10/10
N2 - Significance: S-nitrosylation (SNO) has been identified throughout the body as an important signaling modification both in physiology and a variety of diseases. SNO is a multifaceted post-translational modification, in that it can either act as a signaling molecule itself or as an intermediate to other modifications. Recent Advances and Critical Issues: Through extensive SNO research, we have made progress toward understanding the importance of single cysteine-SNO sites; however, we are just beginning to explore the importance of specific SNO within the context of other SNO sites and post-translational modifications. Additionally, compartmentalization and SNO occupancy may play an important role in the consequences of the SNO modification. Future Directions: In this review, we will consider the context of SNO signaling and discuss how the transient nature of SNO, its role as an oxidative intermediate, and the pattern of SNO, should be considered when determining the impact of SNO signaling. Antioxid. Redox Signal. 19, 1209-1219.
AB - Significance: S-nitrosylation (SNO) has been identified throughout the body as an important signaling modification both in physiology and a variety of diseases. SNO is a multifaceted post-translational modification, in that it can either act as a signaling molecule itself or as an intermediate to other modifications. Recent Advances and Critical Issues: Through extensive SNO research, we have made progress toward understanding the importance of single cysteine-SNO sites; however, we are just beginning to explore the importance of specific SNO within the context of other SNO sites and post-translational modifications. Additionally, compartmentalization and SNO occupancy may play an important role in the consequences of the SNO modification. Future Directions: In this review, we will consider the context of SNO signaling and discuss how the transient nature of SNO, its role as an oxidative intermediate, and the pattern of SNO, should be considered when determining the impact of SNO signaling. Antioxid. Redox Signal. 19, 1209-1219.
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U2 - 10.1089/ars.2012.5056
DO - 10.1089/ars.2012.5056
M3 - Review article
C2 - 23157187
AN - SCOPUS:84876902031
SN - 1523-0864
VL - 19
SP - 1209
EP - 1219
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 11
ER -