S-nitrosylation: NO-related redox signaling to protect against oxidative stress

Junhui Sun, Charles Steenbergen, Elizabeth Murphy

Research output: Contribution to journalReview articlepeer-review

Abstract

Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. S-nitrosylation, the covalent attachment of an NO moiety to sulfhydryl residues of proteins, resulting in the formation of S-nitrosothiols (SNOs), is a prevalent posttranslational protein modification involved in redox-based cellular signaling. Under physiologic conditions, protein S-nitrosylation and SNOs provide protection preventing further cellular oxidative and nitrosative stress. However, oxidative stress and the resultant dysfunction of NO signaling have been implicated in the pathogenesis of cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)1693-1705
Number of pages13
JournalAntioxidants and Redox Signaling
Volume8
Issue number9-10
DOIs
StatePublished - Sep 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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