S-nitrosylation in Parkinson's disease and related neurodegenerative disorders

Kenny K.K. Chung, Valina L. Dawson, Ted M. Dawson

Research output: Contribution to journalReview article

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by impairment in motor function. PD is mostly sporadic, but rare familial cases are also found. The exact pathogenic mechanism is not fully understood, but both genetic and environmental factors are known to be important contributors. In particular, oxidative stress mediated through nitric oxide (NO) is believed to be a prime suspect in the development of PD. NO can exert its effect by modifying different biological molecules, and one of these modifications is through S-nitrosylation. Because of the liable nature of S-nitrosylation, a number of methods are often used to study this modification. We have successfully employed some of these methods and showed that a familial related protein, parkin, can be S-nitrosylated and provide a common pathogenic mechanism for sporadic and familial PD.

Original languageEnglish (US)
Pages (from-to)139-150
Number of pages12
JournalMethods in Enzymology
Volume396
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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