Ruthenium red inhibits tail skin vasodilatation evoked by intracerebroventricular injection of capsaicin in the rat

M. Hajós, G. Janesó, Z. Mari, F. Obál

Research output: Contribution to journalArticle

Abstract

The effect of Ruthenium red on the tail skin vasodilatation evoked by an intracerebroventricular injection of capsaicin was studied in the anesthetized rat. Injection of capsaicin into the lateral ventricle resulted in a marked elevation of the tail skin temperature, indicative of peripheral vasodilatation. Ruthenium red, given by intracerebroventricular injection, significantly inhibited this response, which is known to be mediated by central warmth-sensitive neuronal structures. The findings suggest that the sensitivity to Ruthenium red, reportedly characteristic of the capsaicin-sensitive neurons in the peripheral nervous system, is also a trait of the capsaicin-sensitive nerve cells in the central nervous system. This is the first evidence indicating that similar molecular mechanisms, presumably involving changes in cellular calcium metabolism, contribute to the capsaicin-induced activation of neurons in both the peripheral and central nervous systems.

Original languageEnglish (US)
Pages (from-to)431-433
Number of pages3
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume343
Issue number4
DOIs
StatePublished - Apr 1991
Externally publishedYes

Keywords

  • Capsaicin-sensitive neurons
  • Ruthenium red
  • Thermoregulation
  • Vasodilatation

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Ruthenium red inhibits tail skin vasodilatation evoked by intracerebroventricular injection of capsaicin in the rat'. Together they form a unique fingerprint.

  • Cite this