Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hematopoiesis

Research output: Contribution to journalReview article

Abstract

Immature hematopoietic precursors proliferate as they differentiate, whereas terminal differentiation is associated with cell cycle arrest. Stem cell lineage commitment and subseqent maturation is regulated predominantly by transcription factors. Runx1 and c-Myb act in early stage hematopoietic cells to both stimulate proliferation and differentiation, whereas C/EBPα, and perhaps other C/EBP family members, block progression from G1 to S and induce terminal maturation. Coupling of differentiation to either proliferation or growth arrest by transcription factors is li1kely an important regulatory mechanism in multiple developmental systems.

Original languageEnglish (US)
Pages (from-to)624-629
Number of pages6
JournalJournal of cellular biochemistry
Volume86
Issue number4
DOIs
StatePublished - Aug 14 2002

Keywords

  • C/EBPα
  • Cell cycle
  • Hematopoiesis
  • Runx1
  • c-Myb

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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