Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hematopoiesis

Alan D. Friedman

doi:10.1002/jcb.10271

Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hematopoiesis

Alan D. Friedman

School of Medicine

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Immature hematopoietic precursors proliferate as they differentiate, whereas terminal differentiation is associated with cell cycle arrest. Stem cell lineage commitment and subseqent maturation is regulated predominantly by transcription factors. Runx1 and c-Myb act in early stage hematopoietic cells to both stimulate proliferation and differentiation, whereas C/EBPα, and perhaps other C/EBP family members, block progression from G1 to S and induce terminal maturation. Coupling of differentiation to either proliferation or growth arrest by transcription factors is li1kely an important regulatory mechanism in multiple developmental systems.

Original language	English (US)
Pages (from-to)	624-629
Number of pages	6
Journal	Journal of cellular biochemistry
Volume	86
Issue number	4
DOIs	https://doi.org/10.1002/jcb.10271
State	Published - Aug 14 2002

Keywords

C/EBPα
Cell cycle
Hematopoiesis
Runx1
c-Myb

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1002/jcb.10271

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abstract = "Immature hematopoietic precursors proliferate as they differentiate, whereas terminal differentiation is associated with cell cycle arrest. Stem cell lineage commitment and subseqent maturation is regulated predominantly by transcription factors. Runx1 and c-Myb act in early stage hematopoietic cells to both stimulate proliferation and differentiation, whereas C/EBPα, and perhaps other C/EBP family members, block progression from G1 to S and induce terminal maturation. Coupling of differentiation to either proliferation or growth arrest by transcription factors is li1kely an important regulatory mechanism in multiple developmental systems.",

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T1 - Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hematopoiesis

AU - Friedman, Alan D.

PY - 2002/8/14

Y1 - 2002/8/14

N2 - Immature hematopoietic precursors proliferate as they differentiate, whereas terminal differentiation is associated with cell cycle arrest. Stem cell lineage commitment and subseqent maturation is regulated predominantly by transcription factors. Runx1 and c-Myb act in early stage hematopoietic cells to both stimulate proliferation and differentiation, whereas C/EBPα, and perhaps other C/EBP family members, block progression from G1 to S and induce terminal maturation. Coupling of differentiation to either proliferation or growth arrest by transcription factors is li1kely an important regulatory mechanism in multiple developmental systems.

AB - Immature hematopoietic precursors proliferate as they differentiate, whereas terminal differentiation is associated with cell cycle arrest. Stem cell lineage commitment and subseqent maturation is regulated predominantly by transcription factors. Runx1 and c-Myb act in early stage hematopoietic cells to both stimulate proliferation and differentiation, whereas C/EBPα, and perhaps other C/EBP family members, block progression from G1 to S and induce terminal maturation. Coupling of differentiation to either proliferation or growth arrest by transcription factors is li1kely an important regulatory mechanism in multiple developmental systems.

KW - C/EBPα

KW - Cell cycle

KW - Hematopoiesis

KW - Runx1

KW - c-Myb

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M3 - Review article

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SN - 0730-2312

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SP - 624

EP - 629

JO - Journal of supramolecular structure and cellular biochemistry

JF - Journal of supramolecular structure and cellular biochemistry

IS - 4

ER -

Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hematopoiesis

Abstract

Keywords

ASJC Scopus subject areas

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