Running Elevates Plasma β-Endorphin Immunoreactivity and ACTH in Untrained Human Subjects (41225)

Steven R. Gambert, Thomas L. Garthwaite, Carol H. Pontzer, Elizabeth E. Cook, Felix E. Tristani, Edmund H. Duthie, Donald R. Martinson, Thad C. Hagen, Daniel J. McCarty

Research output: Contribution to journalArticle

Abstract

Twenty minutes of submaximal treadmill running was associated with an elevation in plasma levels of β-endorphin immunoreactivity (P < 0.02). This increase was greater in men (14.9 ± 3.4 fmole/ml) than women (2.6 ± 1.2 fmole/ml) (P < 0.05). Plasma levels of ACTH and growth hormone also increased after running. ACTH increased more in men (7.8 ± 1.1 fmole/ml) than in women (1.1 ± 0.44 fmole/ml) (P < 0.02). There was a similar growth hormone response in both sexes. No correlation can at this time be made with levels in the central nervous system. Changes in plasma levels of β-endorphin immunoreactivity may be responsible for some of the euphoria and analgesia anecdotally associated with running.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume168
Issue number1
DOIs
StatePublished - Oct 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Gambert, S. R., Garthwaite, T. L., Pontzer, C. H., Cook, E. E., Tristani, F. E., Duthie, E. H., Martinson, D. R., Hagen, T. C., & McCarty, D. J. (1981). Running Elevates Plasma β-Endorphin Immunoreactivity and ACTH in Untrained Human Subjects (41225). Proceedings of the Society for Experimental Biology and Medicine, 168(1), 1-4. https://doi.org/10.3181/00379727-168-41225