Running Elevates Plasma β-Endorphin Immunoreactivity and ACTH in Untrained Human Subjects (41225)

Steven R. Gambert; Thomas L. Garthwaite; Carol H. Pontzer; Elizabeth E. Cook; Felix E. Tristani; Edmund H. Duthie; Donald R. Martinson; Thad C. Hagen; Daniel J. McCarty

doi:10.3181/00379727-168-41225

Running Elevates Plasma β-Endorphin Immunoreactivity and ACTH in Untrained Human Subjects (41225)

Steven R. Gambert, Thomas L. Garthwaite, Carol H. Pontzer, Elizabeth E. Cook, Felix E. Tristani, Edmund H. Duthie, Donald R. Martinson, Thad C. Hagen, Daniel J. McCarty

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Twenty minutes of submaximal treadmill running was associated with an elevation in plasma levels of β-endorphin immunoreactivity (P < 0.02). This increase was greater in men (14.9 ± 3.4 fmole/ml) than women (2.6 ± 1.2 fmole/ml) (P < 0.05). Plasma levels of ACTH and growth hormone also increased after running. ACTH increased more in men (7.8 ± 1.1 fmole/ml) than in women (1.1 ± 0.44 fmole/ml) (P < 0.02). There was a similar growth hormone response in both sexes. No correlation can at this time be made with levels in the central nervous system. Changes in plasma levels of β-endorphin immunoreactivity may be responsible for some of the euphoria and analgesia anecdotally associated with running.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	168
Issue number	1
DOIs	https://doi.org/10.3181/00379727-168-41225
State	Published - Oct 1981

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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Gambert, S. R., Garthwaite, T. L., Pontzer, C. H., Cook, E. E., Tristani, F. E., Duthie, E. H., Martinson, D. R., Hagen, T. C., & McCarty, D. J. (1981). Running Elevates Plasma β-Endorphin Immunoreactivity and ACTH in Untrained Human Subjects (41225). Proceedings of the Society for Experimental Biology and Medicine, 168(1), 1-4. https://doi.org/10.3181/00379727-168-41225

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title = "Running Elevates Plasma β-Endorphin Immunoreactivity and ACTH in Untrained Human Subjects (41225)",

abstract = "Twenty minutes of submaximal treadmill running was associated with an elevation in plasma levels of β-endorphin immunoreactivity (P < 0.02). This increase was greater in men (14.9 ± 3.4 fmole/ml) than women (2.6 ± 1.2 fmole/ml) (P < 0.05). Plasma levels of ACTH and growth hormone also increased after running. ACTH increased more in men (7.8 ± 1.1 fmole/ml) than in women (1.1 ± 0.44 fmole/ml) (P < 0.02). There was a similar growth hormone response in both sexes. No correlation can at this time be made with levels in the central nervous system. Changes in plasma levels of β-endorphin immunoreactivity may be responsible for some of the euphoria and analgesia anecdotally associated with running.",

author = "Gambert, {Steven R.} and Garthwaite, {Thomas L.} and Pontzer, {Carol H.} and Cook, {Elizabeth E.} and Tristani, {Felix E.} and Duthie, {Edmund H.} and Martinson, {Donald R.} and Hagen, {Thad C.} and McCarty, {Daniel J.}",

year = "1981",

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doi = "10.3181/00379727-168-41225",

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AU - Gambert, Steven R.

AU - Garthwaite, Thomas L.

AU - Pontzer, Carol H.

AU - Cook, Elizabeth E.

AU - Tristani, Felix E.

AU - Duthie, Edmund H.

AU - Martinson, Donald R.

AU - Hagen, Thad C.

AU - McCarty, Daniel J.

PY - 1981/10

Y1 - 1981/10

N2 - Twenty minutes of submaximal treadmill running was associated with an elevation in plasma levels of β-endorphin immunoreactivity (P < 0.02). This increase was greater in men (14.9 ± 3.4 fmole/ml) than women (2.6 ± 1.2 fmole/ml) (P < 0.05). Plasma levels of ACTH and growth hormone also increased after running. ACTH increased more in men (7.8 ± 1.1 fmole/ml) than in women (1.1 ± 0.44 fmole/ml) (P < 0.02). There was a similar growth hormone response in both sexes. No correlation can at this time be made with levels in the central nervous system. Changes in plasma levels of β-endorphin immunoreactivity may be responsible for some of the euphoria and analgesia anecdotally associated with running.

AB - Twenty minutes of submaximal treadmill running was associated with an elevation in plasma levels of β-endorphin immunoreactivity (P < 0.02). This increase was greater in men (14.9 ± 3.4 fmole/ml) than women (2.6 ± 1.2 fmole/ml) (P < 0.05). Plasma levels of ACTH and growth hormone also increased after running. ACTH increased more in men (7.8 ± 1.1 fmole/ml) than in women (1.1 ± 0.44 fmole/ml) (P < 0.02). There was a similar growth hormone response in both sexes. No correlation can at this time be made with levels in the central nervous system. Changes in plasma levels of β-endorphin immunoreactivity may be responsible for some of the euphoria and analgesia anecdotally associated with running.

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Running Elevates Plasma β-Endorphin Immunoreactivity and ACTH in Untrained Human Subjects (41225)

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