Rules for α-helix termination by glycine

Rajeev Aurora, Rajgopal Srinivasan, George D. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

A predictive rule for protein folding is presented that involves two recurrent glycine-based motifs that cap the carboxyl termini of α helices. In proteins, helices that terminated in glycine residues were found predominantly in one of these two motifs. These glycine structures had a characteristic pattern of polar and apolar residues. Visual inspection of known helical sequences was sufficient to distinguish the two motifs from each other and from internal glycines that fail to terminate helices. These glycine motifs - in which the local sequence selects between available structures - represent an example of a stereochemical rule for protein folding.

Original languageEnglish (US)
Pages (from-to)1126-1130
Number of pages5
JournalScience
Volume264
Issue number5162
DOIs
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Rules for α-helix termination by glycine'. Together they form a unique fingerprint.

Cite this