Rubiasins A-C, new anthracene derivatives from the roots and stems of Rubia cordifolia

Chee Chang Leng Chee Chang, D. Chavez, J. J. Gills, H. H.S. Fong, J. M. Pezzuto, A. D. Kinghorn

Research output: Contribution to journalArticlepeer-review

Abstract

Three new anthracene derivatives, rubiasins A-C (1-3), were isolated from the combined roots and stems of Rubia cordifolia, and their structures were elucidated by spectroscopic analysis. Their absolute configurations were determined by Mosher ester methodology. A known compound, mollugin (4), was obtained as an active antiproliferative principle by bioassay-monitored fractionation using a human colon cancer (Co12) cell line. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)7157-7162
Number of pages6
JournalTetrahedron Letters
Volume41
Issue number37
DOIs
StatePublished - Sep 3 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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