Rubeosis Iridis and Glaucoma Associated with Sickle Cell Retinopathy: A Light and Electron Microscopic Study

Research output: Contribution to journalArticle

Abstract

The ultrastructure of rubeosis iridis in sickle cell-hemoglobin C disease is described for the first time. Findings included open interendothelial cell junctions, intraendothelial cytoplasmic attenuations (fenestrations), and pericyte formation. The ultrastructural appearance of rubeosis iridis gives no clue to the underlying etiology and is similar to that reported in rubeosis associated with diabetes mellitus, central retinal vein occlusion, and uveitis. The electron microscopic findings explain the functional incompetence of rubeotic vessels that are manifested by transmural leakage of fluorescein.

Original languageEnglish (US)
Pages (from-to)1028-1041
Number of pages14
JournalOphthalmology
Volume85
Issue number10
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

Keywords

  • Sickle cell disease
  • central retinal artery occlusion
  • choroidal infarcts
  • diabetes
  • electron microscopy
  • endothelium
  • glaucoma
  • hypoxia
  • ischemia
  • pericytes
  • rubeosis iridis

ASJC Scopus subject areas

  • Ophthalmology

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