Rubella transmission and the risk of congenital rubella syndrome in Liberia: A need to introduce rubella-containing vaccine in the routine immunization program

Abyot Bekele Woyessa, Mohammed Seid Ali, Tiala K. Korkpor, Roland Tuopileyi, Henry T. Kohar, John Dogba, April Baller, Julius Monday, Suleman Abdullahi, Thomas Nagbe, Gertrude Mulbah, Mohammed Kromah, Jeremy Sesay, Kwuakuan Yealue, Tolbert Nyenswah, Mesfin Zbelo Gebrekidan

Research output: Contribution to journalArticle

Abstract

Background: Rubella is an RNA virus in the genus Rubivirus within the Matonaviridae family. Rubella remains a leading vaccine-preventable cause of birth defects. Most African countries including Liberia do not currently provide rubella-containing vaccine (RCV) in their immunization program. We analyzed the existing surveillance data to describe rubella cases and identify the at-risk population. Methods: We conducted a retrospective descriptive statistics on the suspected-measles case-based surveillance data that obtained from the national database. Suspected-measles cases who were negative and indeterminate for measles IgM and tested for rubella IgM were extracted from the database. We used only rubella IgM positive cases to calculate trends and percentages by person, place and time. The cumulative-percent curve was used to visually describe the age distribution of rubella cases. Results: During 2017-2018, a total of 2027 suspected-measles cases with known laboratory results were reported; of which, 1307 were tested for rubella IgM. Among tested cases, 472 (36%) were positive, 769 (59%) were negative and 66 (5%) were indeterminate for rubella IgM. Female contributed 269 (57%) of the confirmed rubella cases respectively. The median age was 7 years with an interquartile range of 5-10 years. From the total rubella cases, 6 (1%) were under 1 year, 109 (23%) were 1-4 years, 207 (44%) were 5-9 years, 87 (18%) were 10-14 years and 56 (12%) were more than or equal to 15 years. Women in their reproductive-age contributed 23 (5%) of rubella cases with 17% positivity rate. Two-thirds or 307 (65%) of the cases were reported from February to May which is dry season in Liberia. Conclusions: Our analysis revealed that rubella was widely circulating in Liberia. Majority of the cases were reported among children < 15 years. However, rubella was also reported among women of reproductive age and infants < 1 year with no report of congenital rubella syndrome (CRS). Detail investigation of rubella cases among infants of < 1 year and women of reproductive age is important to uncover CRS. Establishment of CRS surveillance and the introduction of RCV in the immunization program are crucial to prevent rubella infection and avert the risk of CRS.

Original languageEnglish (US)
Article number813
JournalBMC infectious diseases
Volume19
Issue number1
DOIs
StatePublished - Sep 18 2019
Externally publishedYes

Fingerprint

Liberia
Congenital Rubella Syndrome
Rubella Vaccine
Immunization Programs
Rubella
Immunoglobulin M
Measles
Rubivirus
Databases

Keywords

  • Epidemiology
  • Liberia
  • Measles case-based surveillance
  • Pre-vaccine era
  • Rubella
  • West Africa
  • Women of childbearing age

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Rubella transmission and the risk of congenital rubella syndrome in Liberia : A need to introduce rubella-containing vaccine in the routine immunization program. / Woyessa, Abyot Bekele; Ali, Mohammed Seid; Korkpor, Tiala K.; Tuopileyi, Roland; Kohar, Henry T.; Dogba, John; Baller, April; Monday, Julius; Abdullahi, Suleman; Nagbe, Thomas; Mulbah, Gertrude; Kromah, Mohammed; Sesay, Jeremy; Yealue, Kwuakuan; Nyenswah, Tolbert; Gebrekidan, Mesfin Zbelo.

In: BMC infectious diseases, Vol. 19, No. 1, 813, 18.09.2019.

Research output: Contribution to journalArticle

Woyessa, AB, Ali, MS, Korkpor, TK, Tuopileyi, R, Kohar, HT, Dogba, J, Baller, A, Monday, J, Abdullahi, S, Nagbe, T, Mulbah, G, Kromah, M, Sesay, J, Yealue, K, Nyenswah, T & Gebrekidan, MZ 2019, 'Rubella transmission and the risk of congenital rubella syndrome in Liberia: A need to introduce rubella-containing vaccine in the routine immunization program', BMC infectious diseases, vol. 19, no. 1, 813. https://doi.org/10.1186/s12879-019-4464-7
Woyessa, Abyot Bekele ; Ali, Mohammed Seid ; Korkpor, Tiala K. ; Tuopileyi, Roland ; Kohar, Henry T. ; Dogba, John ; Baller, April ; Monday, Julius ; Abdullahi, Suleman ; Nagbe, Thomas ; Mulbah, Gertrude ; Kromah, Mohammed ; Sesay, Jeremy ; Yealue, Kwuakuan ; Nyenswah, Tolbert ; Gebrekidan, Mesfin Zbelo. / Rubella transmission and the risk of congenital rubella syndrome in Liberia : A need to introduce rubella-containing vaccine in the routine immunization program. In: BMC infectious diseases. 2019 ; Vol. 19, No. 1.
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abstract = "Background: Rubella is an RNA virus in the genus Rubivirus within the Matonaviridae family. Rubella remains a leading vaccine-preventable cause of birth defects. Most African countries including Liberia do not currently provide rubella-containing vaccine (RCV) in their immunization program. We analyzed the existing surveillance data to describe rubella cases and identify the at-risk population. Methods: We conducted a retrospective descriptive statistics on the suspected-measles case-based surveillance data that obtained from the national database. Suspected-measles cases who were negative and indeterminate for measles IgM and tested for rubella IgM were extracted from the database. We used only rubella IgM positive cases to calculate trends and percentages by person, place and time. The cumulative-percent curve was used to visually describe the age distribution of rubella cases. Results: During 2017-2018, a total of 2027 suspected-measles cases with known laboratory results were reported; of which, 1307 were tested for rubella IgM. Among tested cases, 472 (36{\%}) were positive, 769 (59{\%}) were negative and 66 (5{\%}) were indeterminate for rubella IgM. Female contributed 269 (57{\%}) of the confirmed rubella cases respectively. The median age was 7 years with an interquartile range of 5-10 years. From the total rubella cases, 6 (1{\%}) were under 1 year, 109 (23{\%}) were 1-4 years, 207 (44{\%}) were 5-9 years, 87 (18{\%}) were 10-14 years and 56 (12{\%}) were more than or equal to 15 years. Women in their reproductive-age contributed 23 (5{\%}) of rubella cases with 17{\%} positivity rate. Two-thirds or 307 (65{\%}) of the cases were reported from February to May which is dry season in Liberia. Conclusions: Our analysis revealed that rubella was widely circulating in Liberia. Majority of the cases were reported among children < 15 years. However, rubella was also reported among women of reproductive age and infants < 1 year with no report of congenital rubella syndrome (CRS). Detail investigation of rubella cases among infants of < 1 year and women of reproductive age is important to uncover CRS. Establishment of CRS surveillance and the introduction of RCV in the immunization program are crucial to prevent rubella infection and avert the risk of CRS.",
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TY - JOUR

T1 - Rubella transmission and the risk of congenital rubella syndrome in Liberia

T2 - A need to introduce rubella-containing vaccine in the routine immunization program

AU - Woyessa, Abyot Bekele

AU - Ali, Mohammed Seid

AU - Korkpor, Tiala K.

AU - Tuopileyi, Roland

AU - Kohar, Henry T.

AU - Dogba, John

AU - Baller, April

AU - Monday, Julius

AU - Abdullahi, Suleman

AU - Nagbe, Thomas

AU - Mulbah, Gertrude

AU - Kromah, Mohammed

AU - Sesay, Jeremy

AU - Yealue, Kwuakuan

AU - Nyenswah, Tolbert

AU - Gebrekidan, Mesfin Zbelo

PY - 2019/9/18

Y1 - 2019/9/18

N2 - Background: Rubella is an RNA virus in the genus Rubivirus within the Matonaviridae family. Rubella remains a leading vaccine-preventable cause of birth defects. Most African countries including Liberia do not currently provide rubella-containing vaccine (RCV) in their immunization program. We analyzed the existing surveillance data to describe rubella cases and identify the at-risk population. Methods: We conducted a retrospective descriptive statistics on the suspected-measles case-based surveillance data that obtained from the national database. Suspected-measles cases who were negative and indeterminate for measles IgM and tested for rubella IgM were extracted from the database. We used only rubella IgM positive cases to calculate trends and percentages by person, place and time. The cumulative-percent curve was used to visually describe the age distribution of rubella cases. Results: During 2017-2018, a total of 2027 suspected-measles cases with known laboratory results were reported; of which, 1307 were tested for rubella IgM. Among tested cases, 472 (36%) were positive, 769 (59%) were negative and 66 (5%) were indeterminate for rubella IgM. Female contributed 269 (57%) of the confirmed rubella cases respectively. The median age was 7 years with an interquartile range of 5-10 years. From the total rubella cases, 6 (1%) were under 1 year, 109 (23%) were 1-4 years, 207 (44%) were 5-9 years, 87 (18%) were 10-14 years and 56 (12%) were more than or equal to 15 years. Women in their reproductive-age contributed 23 (5%) of rubella cases with 17% positivity rate. Two-thirds or 307 (65%) of the cases were reported from February to May which is dry season in Liberia. Conclusions: Our analysis revealed that rubella was widely circulating in Liberia. Majority of the cases were reported among children < 15 years. However, rubella was also reported among women of reproductive age and infants < 1 year with no report of congenital rubella syndrome (CRS). Detail investigation of rubella cases among infants of < 1 year and women of reproductive age is important to uncover CRS. Establishment of CRS surveillance and the introduction of RCV in the immunization program are crucial to prevent rubella infection and avert the risk of CRS.

AB - Background: Rubella is an RNA virus in the genus Rubivirus within the Matonaviridae family. Rubella remains a leading vaccine-preventable cause of birth defects. Most African countries including Liberia do not currently provide rubella-containing vaccine (RCV) in their immunization program. We analyzed the existing surveillance data to describe rubella cases and identify the at-risk population. Methods: We conducted a retrospective descriptive statistics on the suspected-measles case-based surveillance data that obtained from the national database. Suspected-measles cases who were negative and indeterminate for measles IgM and tested for rubella IgM were extracted from the database. We used only rubella IgM positive cases to calculate trends and percentages by person, place and time. The cumulative-percent curve was used to visually describe the age distribution of rubella cases. Results: During 2017-2018, a total of 2027 suspected-measles cases with known laboratory results were reported; of which, 1307 were tested for rubella IgM. Among tested cases, 472 (36%) were positive, 769 (59%) were negative and 66 (5%) were indeterminate for rubella IgM. Female contributed 269 (57%) of the confirmed rubella cases respectively. The median age was 7 years with an interquartile range of 5-10 years. From the total rubella cases, 6 (1%) were under 1 year, 109 (23%) were 1-4 years, 207 (44%) were 5-9 years, 87 (18%) were 10-14 years and 56 (12%) were more than or equal to 15 years. Women in their reproductive-age contributed 23 (5%) of rubella cases with 17% positivity rate. Two-thirds or 307 (65%) of the cases were reported from February to May which is dry season in Liberia. Conclusions: Our analysis revealed that rubella was widely circulating in Liberia. Majority of the cases were reported among children < 15 years. However, rubella was also reported among women of reproductive age and infants < 1 year with no report of congenital rubella syndrome (CRS). Detail investigation of rubella cases among infants of < 1 year and women of reproductive age is important to uncover CRS. Establishment of CRS surveillance and the introduction of RCV in the immunization program are crucial to prevent rubella infection and avert the risk of CRS.

KW - Epidemiology

KW - Liberia

KW - Measles case-based surveillance

KW - Pre-vaccine era

KW - Rubella

KW - West Africa

KW - Women of childbearing age

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