Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats

Kerstin Stemmer, Maximilian Bielohuby, Bernadette E. Grayson, Denovan P. Begg, Adam P. Chambers, Christina Neff, Stephen C. Woods, Reinhold G. Erben, Matthias H. Tschöp, Martin Bidlingmaier, Thomas Clemens, Randy J. Seeley

Research output: Contribution to journalArticle

Abstract

The most effective treatment for obesity is bariatric surgery. However, there is increasing concern that bariatric surgery can cause nutrient deficiencies that translate into metabolic bone disease. Whether this is true for all surgery types is not yet clear. We therefore investigated the effects of 2 commonly applied bariatric surgeries (Roux-en-Y gastric bypass [RYGB] and vertical sleeve gastrectomy) on energy and bone metabolism in rats 60 days after surgery. Both surgeries resulted in similar reductions of body weight, body fat, and food intake. Glucose tolerance was improved to a similar extent after both surgeries and was accompanied by increased postprandial secretion of glucose-dependent insulinotropic peptide. Using microcomputed tomography, we found that, relative to sham-operated rats, bone volume was significantly reduced after RYGB but not vertical sleeve gastrectomy. RYGB rats also had markedly reduced lipid absorption from the intestine and significantly lower serum 25-hydroxyvitamin D and calcium levels. Importantly, dietary supplementation with calcium and vitamin D could not fully rescue the reduced bone volume after RYGB surgery. Both surgeries resulted in a significant increase in stomach pH, which may have worsened the malabsorption in RYGB rats. Our findings suggest that bone loss in RYGB rats is not exclusively driven by calcium and vitamin D malabsorption but also by additional factors that may not be rescuable by dietary supplementation. These data point toward important similarities and differences between bariatric procedures that should be considered in clinical settings as guidance for which procedure will be best for specific patient populations.

Original languageEnglish (US)
Pages (from-to)2015-2024
Number of pages10
JournalEndocrinology
Volume154
Issue number6
DOIs
StatePublished - Jun 1 2013

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Gastric Bypass
Gastrectomy
Bone and Bones
Bariatric Surgery
Dietary Supplements
Calcium
Vitamin D
Gastric Inhibitory Polypeptide
Bariatrics
X-Ray Microtomography
Metabolic Bone Diseases
Ambulatory Surgical Procedures
Energy Metabolism
Intestines
Adipose Tissue
Stomach
Obesity
Eating
Body Weight
Lipids

ASJC Scopus subject areas

  • Endocrinology

Cite this

Stemmer, K., Bielohuby, M., Grayson, B. E., Begg, D. P., Chambers, A. P., Neff, C., ... Seeley, R. J. (2013). Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology, 154(6), 2015-2024. https://doi.org/10.1210/en.2012-2130

Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. / Stemmer, Kerstin; Bielohuby, Maximilian; Grayson, Bernadette E.; Begg, Denovan P.; Chambers, Adam P.; Neff, Christina; Woods, Stephen C.; Erben, Reinhold G.; Tschöp, Matthias H.; Bidlingmaier, Martin; Clemens, Thomas; Seeley, Randy J.

In: Endocrinology, Vol. 154, No. 6, 01.06.2013, p. 2015-2024.

Research output: Contribution to journalArticle

Stemmer, K, Bielohuby, M, Grayson, BE, Begg, DP, Chambers, AP, Neff, C, Woods, SC, Erben, RG, Tschöp, MH, Bidlingmaier, M, Clemens, T & Seeley, RJ 2013, 'Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats', Endocrinology, vol. 154, no. 6, pp. 2015-2024. https://doi.org/10.1210/en.2012-2130
Stemmer K, Bielohuby M, Grayson BE, Begg DP, Chambers AP, Neff C et al. Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology. 2013 Jun 1;154(6):2015-2024. https://doi.org/10.1210/en.2012-2130
Stemmer, Kerstin ; Bielohuby, Maximilian ; Grayson, Bernadette E. ; Begg, Denovan P. ; Chambers, Adam P. ; Neff, Christina ; Woods, Stephen C. ; Erben, Reinhold G. ; Tschöp, Matthias H. ; Bidlingmaier, Martin ; Clemens, Thomas ; Seeley, Randy J. / Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. In: Endocrinology. 2013 ; Vol. 154, No. 6. pp. 2015-2024.
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