Routes for Formation of S-Nitrosothiols in Blood

Enika Nagababu, Joseph M. Rifkind

Research output: Contribution to journalReview articlepeer-review


S-nitrosothiols (RSNO) are involved in post-translational modifications of many proteins analogous to protein phosphorylation. In addition, RSNO have many physiological roles similar to nitric oxide (NO), which are presumably involving the release of NO from the RSNO. However, the much longer life span in biological systems for RSNO than NO suggests a dominant role for RSNO in mediating NO bioactivity. RSNO are detected in plasma in low nanomolar levels in healthy human subjects. These RSNO are believed to be redirecting the NO to the vasculature. However, the mechanism for the formation of RSNO in vivo has not been established. We have reviewed the reactions of NO with oxygen, metalloproteins, and free radicals that can lead to the formation of RSNO and have evaluated the potential for each mechanism to provide a source for RSNO in vivo.

Original languageEnglish (US)
Pages (from-to)385-398
Number of pages14
JournalCell Biochemistry and Biophysics
Issue number2
StatePublished - Nov 2013
Externally publishedYes


  • Blood
  • Hemoglobin
  • Metalloproteins
  • Nitric oxide
  • S-nitrosation
  • S-nitrosothiols

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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