Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea

Jayashree Aiyar, M. K. Bhan, Nita Bhandari, Ramesh Kumar, Pushker Raj, Sunil Sazawal

Research output: Contribution to journalArticle

Abstract

The reliability of saliva as an indicator of rotavirus infection was assessed among 15 infants (3–12 months) with rotaviral and 15 with nonrotaviral diarrhea. Paired salivary samples collected during acute and convalescent phases were tested for rotavirus-specific IgA and IgM byan ELISA. The sensitivity of IgA or IgM alone to predict infection was 53.3% and 46.6%, respectively; used in conjunction, the sensitivity rose to 80%. It seems that infants with rotaviral diarrhea mount mucosal antibody responses as reflected in their saliva; possibly salivary antibodies could beused to evaluate vaccine “take” in rotavirus vaccine trials.

Original languageEnglish (US)
Pages (from-to)1383-1384
Number of pages2
JournalJournal of Infectious Diseases
Volume162
Issue number6
DOIs
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Aiyar, J., Bhan, M. K., Bhandari, N., Kumar, R., Raj, P., & Sazawal, S. (1990). Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea. Journal of Infectious Diseases, 162(6), 1383-1384. https://doi.org/10.1093/infdis/162.6.1383