La mortalité du rotavirus en Inde: Estimations fondáes sur une enquête nationale représentative des décés par diarrheáe

Translated title of the contribution: Rotavirus mortality in India: Estimates based on a nationally representative survey of diarrhoeal deaths

Shaun K. Morris, Shally Awasthi, Ajay Khera, Diego G. Bassani, Gagandeep Kang, Umesh D. Parashar, Rajesh Kumar, Anita Shet, Roger I. Glass, Prabhat Jha

Research output: Contribution to journalArticle

Abstract

Objective To estimate the number of rotavirus-associated deaths among Indian children younger than five years. Methods We surveyed more than 23 000 child deaths from a nationally representative survey of 1.1 million Indian households during 2001-2003. Diarrhoeal deaths were characterized by region, age and sex and were combined with the proportion of deaths attributable to rotavirus, as determined by hospital microbiologic data collected by the Indian Rotavirus Strain Surveillance Network from December 2005 to November 2007. Rotavirus vaccine efficacy data from clinical trials in developing countries were used to estimate the number of deaths preventable by a national vaccination programme. Data were analysed using Stata SE version 10. Findings Rotavirus caused an estimated 113 000 deaths (99% confidence interval, CI: 86 000-155 000); 50% (54 700) and 75% (85 400) occurred before one and two years of age, respectively. One child in 242 died from rotavirus infection before five years of age. Rotavirus-associated mortality rates overall, among girls and among boys were 4.14 (99% CI: 3.14-5.68), 4.89 (99% CI: 3.75-6.79) and 3.45 (99% CI: 2.58-4.66) deaths per 1000 live births, respectively. Rates were highest in Bihar, Uttar Pradesh and Madhya Pradesh, which together accounted for > 50% of deaths (64 400) nationally. Rotavirus vaccine could prevent 41 000-48 000 deaths among children aged 3-59 months. Conclusion The burden of rotavirus-associated mortality is high among Indian children, highlighting the potential benefits of rotavirus vaccination.

Original languageFrench
Pages (from-to)720-727
Number of pages8
JournalBulletin of the World Health Organization
Volume90
Issue number10
DOIs
StatePublished - Oct 2012
Externally publishedYes

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Rotavirus
India
Mortality
Rotavirus Vaccines
Vaccination
Rotavirus Infections
Surveys and Questionnaires
Live Birth
Developing Countries
Clinical Trials
Confidence Intervals

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

La mortalité du rotavirus en Inde : Estimations fondáes sur une enquête nationale représentative des décés par diarrheáe. / Morris, Shaun K.; Awasthi, Shally; Khera, Ajay; Bassani, Diego G.; Kang, Gagandeep; Parashar, Umesh D.; Kumar, Rajesh; Shet, Anita; Glass, Roger I.; Jha, Prabhat.

In: Bulletin of the World Health Organization, Vol. 90, No. 10, 10.2012, p. 720-727.

Research output: Contribution to journalArticle

Morris, Shaun K. ; Awasthi, Shally ; Khera, Ajay ; Bassani, Diego G. ; Kang, Gagandeep ; Parashar, Umesh D. ; Kumar, Rajesh ; Shet, Anita ; Glass, Roger I. ; Jha, Prabhat. / La mortalité du rotavirus en Inde : Estimations fondáes sur une enquête nationale représentative des décés par diarrheáe. In: Bulletin of the World Health Organization. 2012 ; Vol. 90, No. 10. pp. 720-727.
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abstract = "Objective To estimate the number of rotavirus-associated deaths among Indian children younger than five years. Methods We surveyed more than 23 000 child deaths from a nationally representative survey of 1.1 million Indian households during 2001-2003. Diarrhoeal deaths were characterized by region, age and sex and were combined with the proportion of deaths attributable to rotavirus, as determined by hospital microbiologic data collected by the Indian Rotavirus Strain Surveillance Network from December 2005 to November 2007. Rotavirus vaccine efficacy data from clinical trials in developing countries were used to estimate the number of deaths preventable by a national vaccination programme. Data were analysed using Stata SE version 10. Findings Rotavirus caused an estimated 113 000 deaths (99{\%} confidence interval, CI: 86 000-155 000); 50{\%} (54 700) and 75{\%} (85 400) occurred before one and two years of age, respectively. One child in 242 died from rotavirus infection before five years of age. Rotavirus-associated mortality rates overall, among girls and among boys were 4.14 (99{\%} CI: 3.14-5.68), 4.89 (99{\%} CI: 3.75-6.79) and 3.45 (99{\%} CI: 2.58-4.66) deaths per 1000 live births, respectively. Rates were highest in Bihar, Uttar Pradesh and Madhya Pradesh, which together accounted for > 50{\%} of deaths (64 400) nationally. Rotavirus vaccine could prevent 41 000-48 000 deaths among children aged 3-59 months. Conclusion The burden of rotavirus-associated mortality is high among Indian children, highlighting the potential benefits of rotavirus vaccination.",
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AU - Khera, Ajay

AU - Bassani, Diego G.

AU - Kang, Gagandeep

AU - Parashar, Umesh D.

AU - Kumar, Rajesh

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AB - Objective To estimate the number of rotavirus-associated deaths among Indian children younger than five years. Methods We surveyed more than 23 000 child deaths from a nationally representative survey of 1.1 million Indian households during 2001-2003. Diarrhoeal deaths were characterized by region, age and sex and were combined with the proportion of deaths attributable to rotavirus, as determined by hospital microbiologic data collected by the Indian Rotavirus Strain Surveillance Network from December 2005 to November 2007. Rotavirus vaccine efficacy data from clinical trials in developing countries were used to estimate the number of deaths preventable by a national vaccination programme. Data were analysed using Stata SE version 10. Findings Rotavirus caused an estimated 113 000 deaths (99% confidence interval, CI: 86 000-155 000); 50% (54 700) and 75% (85 400) occurred before one and two years of age, respectively. One child in 242 died from rotavirus infection before five years of age. Rotavirus-associated mortality rates overall, among girls and among boys were 4.14 (99% CI: 3.14-5.68), 4.89 (99% CI: 3.75-6.79) and 3.45 (99% CI: 2.58-4.66) deaths per 1000 live births, respectively. Rates were highest in Bihar, Uttar Pradesh and Madhya Pradesh, which together accounted for > 50% of deaths (64 400) nationally. Rotavirus vaccine could prevent 41 000-48 000 deaths among children aged 3-59 months. Conclusion The burden of rotavirus-associated mortality is high among Indian children, highlighting the potential benefits of rotavirus vaccination.

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