Rotaviral immunity in gnotobiotic calves: Heterologous resistance to human virus induced by bovine virus

Richard G. Wyatt; Charles A. Mebus; Robert H. Yolken; Anthony R. Kalica; Harvey D. James; Albert Z. Kapikian; Robert M. Chanock

doi:10.1126/science.216077

Rotaviral immunity in gnotobiotic calves: Heterologous resistance to human virus induced by bovine virus

Richard G. Wyatt, Charles A. Mebus, Robert H. Yolken, Anthony R. Kalica, Harvey D. James, Albert Z. Kapikian, Robert M. Chanock

Research output: Contribution to journal › Article › peer-review

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Abstract

The possibility of immunizing human infants against rotaviruses, which cause severe dehydrating diarrheal disease, may depend on the use of a related rotavirus, derived from another animal species, as a source of antigen. To test the feasibility of this approach, calves were infected in utero with a bovine rotavirus and challenged with bovine or human type 2 rotavirus shortly after birth. Infection in utero with bovine rotavirus induced resistance to diarrheal disease caused by the human virus as well as the homologous bovine virus. These data suggest that the bovine virus is sufficiently related antigenically to the human type 2 virus to warrant further evaluation of the former as a source of vaccine.

Original language	English (US)
Pages (from-to)	548-550
Number of pages	3
Journal	Science
Volume	203
Issue number	4380
DOIs	https://doi.org/10.1126/science.216077
State	Published - Jan 1 1979
Externally published	Yes

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title = "Rotaviral immunity in gnotobiotic calves: Heterologous resistance to human virus induced by bovine virus",

abstract = "The possibility of immunizing human infants against rotaviruses, which cause severe dehydrating diarrheal disease, may depend on the use of a related rotavirus, derived from another animal species, as a source of antigen. To test the feasibility of this approach, calves were infected in utero with a bovine rotavirus and challenged with bovine or human type 2 rotavirus shortly after birth. Infection in utero with bovine rotavirus induced resistance to diarrheal disease caused by the human virus as well as the homologous bovine virus. These data suggest that the bovine virus is sufficiently related antigenically to the human type 2 virus to warrant further evaluation of the former as a source of vaccine.",

author = "Wyatt, {Richard G.} and Mebus, {Charles A.} and Yolken, {Robert H.} and Kalica, {Anthony R.} and James, {Harvey D.} and Kapikian, {Albert Z.} and Chanock, {Robert M.}",

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T1 - Rotaviral immunity in gnotobiotic calves

T2 - Heterologous resistance to human virus induced by bovine virus

AU - Wyatt, Richard G.

AU - Mebus, Charles A.

AU - Yolken, Robert H.

AU - Kalica, Anthony R.

AU - James, Harvey D.

AU - Kapikian, Albert Z.

AU - Chanock, Robert M.

PY - 1979/1/1

Y1 - 1979/1/1

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AB - The possibility of immunizing human infants against rotaviruses, which cause severe dehydrating diarrheal disease, may depend on the use of a related rotavirus, derived from another animal species, as a source of antigen. To test the feasibility of this approach, calves were infected in utero with a bovine rotavirus and challenged with bovine or human type 2 rotavirus shortly after birth. Infection in utero with bovine rotavirus induced resistance to diarrheal disease caused by the human virus as well as the homologous bovine virus. These data suggest that the bovine virus is sufficiently related antigenically to the human type 2 virus to warrant further evaluation of the former as a source of vaccine.

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Rotaviral immunity in gnotobiotic calves: Heterologous resistance to human virus induced by bovine virus

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