Rotation of the junction of the outflow tract and great arteries in the embryonic human heart

M. P. Lomonico, G. W. Moore, G. M. Hutchins

    Research output: Contribution to journalArticle

    Abstract

    The factors which give rise to the normal relationship between the great arteries and their respective ventricles are unknown. The developmental anatomy of this region was studied by using frontal, saggital, or transverse series histologic sections of 17 normal human embryos of Carnegie stages 15-19 from the Carnegie Embryological Collection. Distances and angles between major anatomic landmarks were determined by using computer reconstructions of the serially sectioned embryos, three-dimensional analytic geometry, and Euclidean distance formulas. The findings show that between stages 15 and 19 there is a marked rotation of the axis of the semilunar valves: frontal 121° counterclockwise, sagittal 196° counterclockwise, and transverse 240° clockwise. Simultaneously the great arteries lengthen at a faster rate than the rest of the great arteries. These results suggest that the changing rate of growth between the great arteries and the heart is necessary to align the great arteries, the semilunar valves, and the muscular outflow tract septum appropriately with respect to the interventricular septum. Reductions in the rate of growth of the great arteries relative to the heart could, by causing changes in the rotation of great arteries and outflow tract septum, have a role in the pathogenesis of cardiovascular malformations such as tetralogy of Fallot and transposition of the great arteries.

    Original languageEnglish (US)
    Pages (from-to)544-549
    Number of pages6
    JournalAnatomical Record
    Volume216
    Issue number4
    StatePublished - 1986

    Fingerprint

    arteries
    Arteries
    heart
    Embryonic Structures
    embryo (animal)
    Anatomic Landmarks
    Transposition of Great Vessels
    Tetralogy of Fallot
    Growth
    Anatomy
    pathogenesis

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences (miscellaneous)
    • Anatomy

    Cite this

    Lomonico, M. P., Moore, G. W., & Hutchins, G. M. (1986). Rotation of the junction of the outflow tract and great arteries in the embryonic human heart. Anatomical Record, 216(4), 544-549.

    Rotation of the junction of the outflow tract and great arteries in the embryonic human heart. / Lomonico, M. P.; Moore, G. W.; Hutchins, G. M.

    In: Anatomical Record, Vol. 216, No. 4, 1986, p. 544-549.

    Research output: Contribution to journalArticle

    Lomonico, MP, Moore, GW & Hutchins, GM 1986, 'Rotation of the junction of the outflow tract and great arteries in the embryonic human heart', Anatomical Record, vol. 216, no. 4, pp. 544-549.
    Lomonico, M. P. ; Moore, G. W. ; Hutchins, G. M. / Rotation of the junction of the outflow tract and great arteries in the embryonic human heart. In: Anatomical Record. 1986 ; Vol. 216, No. 4. pp. 544-549.
    @article{69506f63b2fd4d07914bb3d8e2b381f6,
    title = "Rotation of the junction of the outflow tract and great arteries in the embryonic human heart",
    abstract = "The factors which give rise to the normal relationship between the great arteries and their respective ventricles are unknown. The developmental anatomy of this region was studied by using frontal, saggital, or transverse series histologic sections of 17 normal human embryos of Carnegie stages 15-19 from the Carnegie Embryological Collection. Distances and angles between major anatomic landmarks were determined by using computer reconstructions of the serially sectioned embryos, three-dimensional analytic geometry, and Euclidean distance formulas. The findings show that between stages 15 and 19 there is a marked rotation of the axis of the semilunar valves: frontal 121° counterclockwise, sagittal 196° counterclockwise, and transverse 240° clockwise. Simultaneously the great arteries lengthen at a faster rate than the rest of the great arteries. These results suggest that the changing rate of growth between the great arteries and the heart is necessary to align the great arteries, the semilunar valves, and the muscular outflow tract septum appropriately with respect to the interventricular septum. Reductions in the rate of growth of the great arteries relative to the heart could, by causing changes in the rotation of great arteries and outflow tract septum, have a role in the pathogenesis of cardiovascular malformations such as tetralogy of Fallot and transposition of the great arteries.",
    author = "Lomonico, {M. P.} and Moore, {G. W.} and Hutchins, {G. M.}",
    year = "1986",
    language = "English (US)",
    volume = "216",
    pages = "544--549",
    journal = "Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology",
    issn = "1552-4884",
    publisher = "Wiley-Liss Inc.",
    number = "4",

    }

    TY - JOUR

    T1 - Rotation of the junction of the outflow tract and great arteries in the embryonic human heart

    AU - Lomonico, M. P.

    AU - Moore, G. W.

    AU - Hutchins, G. M.

    PY - 1986

    Y1 - 1986

    N2 - The factors which give rise to the normal relationship between the great arteries and their respective ventricles are unknown. The developmental anatomy of this region was studied by using frontal, saggital, or transverse series histologic sections of 17 normal human embryos of Carnegie stages 15-19 from the Carnegie Embryological Collection. Distances and angles between major anatomic landmarks were determined by using computer reconstructions of the serially sectioned embryos, three-dimensional analytic geometry, and Euclidean distance formulas. The findings show that between stages 15 and 19 there is a marked rotation of the axis of the semilunar valves: frontal 121° counterclockwise, sagittal 196° counterclockwise, and transverse 240° clockwise. Simultaneously the great arteries lengthen at a faster rate than the rest of the great arteries. These results suggest that the changing rate of growth between the great arteries and the heart is necessary to align the great arteries, the semilunar valves, and the muscular outflow tract septum appropriately with respect to the interventricular septum. Reductions in the rate of growth of the great arteries relative to the heart could, by causing changes in the rotation of great arteries and outflow tract septum, have a role in the pathogenesis of cardiovascular malformations such as tetralogy of Fallot and transposition of the great arteries.

    AB - The factors which give rise to the normal relationship between the great arteries and their respective ventricles are unknown. The developmental anatomy of this region was studied by using frontal, saggital, or transverse series histologic sections of 17 normal human embryos of Carnegie stages 15-19 from the Carnegie Embryological Collection. Distances and angles between major anatomic landmarks were determined by using computer reconstructions of the serially sectioned embryos, three-dimensional analytic geometry, and Euclidean distance formulas. The findings show that between stages 15 and 19 there is a marked rotation of the axis of the semilunar valves: frontal 121° counterclockwise, sagittal 196° counterclockwise, and transverse 240° clockwise. Simultaneously the great arteries lengthen at a faster rate than the rest of the great arteries. These results suggest that the changing rate of growth between the great arteries and the heart is necessary to align the great arteries, the semilunar valves, and the muscular outflow tract septum appropriately with respect to the interventricular septum. Reductions in the rate of growth of the great arteries relative to the heart could, by causing changes in the rotation of great arteries and outflow tract septum, have a role in the pathogenesis of cardiovascular malformations such as tetralogy of Fallot and transposition of the great arteries.

    UR - http://www.scopus.com/inward/record.url?scp=0022994539&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0022994539&partnerID=8YFLogxK

    M3 - Article

    C2 - 3800002

    AN - SCOPUS:0022994539

    VL - 216

    SP - 544

    EP - 549

    JO - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology

    JF - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology

    SN - 1552-4884

    IS - 4

    ER -