Rostral ventrolateral medulla

Selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons

Christopher A Ross, D. A. Ruggiero, T. H. Joh, D. H. Park, D. J. Reis

Research output: Contribution to journalArticle

Abstract

Anterograde, retrograde, and combined transport methods were used to describe the descending efferent projections of a region of rostral ventrolateral medullary reticular formation important in cardiovascular control. We have termed this region, which contains C1 adrenaline-synthesizing neurons, the nucleus reticularis rostroventrolateralis (RVL). Efferent projections from the RVL innervate all segmental levels of the thoracic intermediolateral and intermediomedial columns as shown using retrograde transport of lectin-conjugated horseradish peroxidase (HRP) or fast blue dye, and anterograde transport of either HRP or labeled amino acids. The projection is highly specific in that there are no projections to thoracic dorsal or ventral horns. This innervaton corresponds to the distribution of preganglionic sympathetic neurons in the intermediolateral column. In particular, terminals surround neurons projecting to the adrenal medulla, as demonstrated by combined anterograde and retrograde transport methods at the light level. Terminals containing phenylethanolamine-N-methyl transferase (PNMT) were mapped using immunocytochemical techniques. PNMT-labeled terminals were present at all levels of thoracic intermediolateral column, in a distribution similar to that of the descending projections from the RVL. We have previously shown, using double label techniques (Ross et al., '81-'83), that many of the spinal projections of the RVL originate from C1 neurons. These data support our suggestion that certain bulbospinal neurons within the RVL, in particular the C1 neurons, are crucial for tonic vasomotor control.

Original languageEnglish (US)
Pages (from-to)168-185
Number of pages18
JournalJournal of Comparative Neurology
Volume228
Issue number2
StatePublished - 1984

Fingerprint

Epinephrine
Thorax
Neurons
Horseradish Peroxidase
Transferases
Adrenal Medulla
Reticular Formation
Horns
Lectins
Coloring Agents
Light
Amino Acids
N-phenylethanolamine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rostral ventrolateral medulla : Selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons. / Ross, Christopher A; Ruggiero, D. A.; Joh, T. H.; Park, D. H.; Reis, D. J.

In: Journal of Comparative Neurology, Vol. 228, No. 2, 1984, p. 168-185.

Research output: Contribution to journalArticle

@article{db18519f355e4781a2f7df15fb0f0dfa,
title = "Rostral ventrolateral medulla: Selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons",
abstract = "Anterograde, retrograde, and combined transport methods were used to describe the descending efferent projections of a region of rostral ventrolateral medullary reticular formation important in cardiovascular control. We have termed this region, which contains C1 adrenaline-synthesizing neurons, the nucleus reticularis rostroventrolateralis (RVL). Efferent projections from the RVL innervate all segmental levels of the thoracic intermediolateral and intermediomedial columns as shown using retrograde transport of lectin-conjugated horseradish peroxidase (HRP) or fast blue dye, and anterograde transport of either HRP or labeled amino acids. The projection is highly specific in that there are no projections to thoracic dorsal or ventral horns. This innervaton corresponds to the distribution of preganglionic sympathetic neurons in the intermediolateral column. In particular, terminals surround neurons projecting to the adrenal medulla, as demonstrated by combined anterograde and retrograde transport methods at the light level. Terminals containing phenylethanolamine-N-methyl transferase (PNMT) were mapped using immunocytochemical techniques. PNMT-labeled terminals were present at all levels of thoracic intermediolateral column, in a distribution similar to that of the descending projections from the RVL. We have previously shown, using double label techniques (Ross et al., '81-'83), that many of the spinal projections of the RVL originate from C1 neurons. These data support our suggestion that certain bulbospinal neurons within the RVL, in particular the C1 neurons, are crucial for tonic vasomotor control.",
author = "Ross, {Christopher A} and Ruggiero, {D. A.} and Joh, {T. H.} and Park, {D. H.} and Reis, {D. J.}",
year = "1984",
language = "English (US)",
volume = "228",
pages = "168--185",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Rostral ventrolateral medulla

T2 - Selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons

AU - Ross, Christopher A

AU - Ruggiero, D. A.

AU - Joh, T. H.

AU - Park, D. H.

AU - Reis, D. J.

PY - 1984

Y1 - 1984

N2 - Anterograde, retrograde, and combined transport methods were used to describe the descending efferent projections of a region of rostral ventrolateral medullary reticular formation important in cardiovascular control. We have termed this region, which contains C1 adrenaline-synthesizing neurons, the nucleus reticularis rostroventrolateralis (RVL). Efferent projections from the RVL innervate all segmental levels of the thoracic intermediolateral and intermediomedial columns as shown using retrograde transport of lectin-conjugated horseradish peroxidase (HRP) or fast blue dye, and anterograde transport of either HRP or labeled amino acids. The projection is highly specific in that there are no projections to thoracic dorsal or ventral horns. This innervaton corresponds to the distribution of preganglionic sympathetic neurons in the intermediolateral column. In particular, terminals surround neurons projecting to the adrenal medulla, as demonstrated by combined anterograde and retrograde transport methods at the light level. Terminals containing phenylethanolamine-N-methyl transferase (PNMT) were mapped using immunocytochemical techniques. PNMT-labeled terminals were present at all levels of thoracic intermediolateral column, in a distribution similar to that of the descending projections from the RVL. We have previously shown, using double label techniques (Ross et al., '81-'83), that many of the spinal projections of the RVL originate from C1 neurons. These data support our suggestion that certain bulbospinal neurons within the RVL, in particular the C1 neurons, are crucial for tonic vasomotor control.

AB - Anterograde, retrograde, and combined transport methods were used to describe the descending efferent projections of a region of rostral ventrolateral medullary reticular formation important in cardiovascular control. We have termed this region, which contains C1 adrenaline-synthesizing neurons, the nucleus reticularis rostroventrolateralis (RVL). Efferent projections from the RVL innervate all segmental levels of the thoracic intermediolateral and intermediomedial columns as shown using retrograde transport of lectin-conjugated horseradish peroxidase (HRP) or fast blue dye, and anterograde transport of either HRP or labeled amino acids. The projection is highly specific in that there are no projections to thoracic dorsal or ventral horns. This innervaton corresponds to the distribution of preganglionic sympathetic neurons in the intermediolateral column. In particular, terminals surround neurons projecting to the adrenal medulla, as demonstrated by combined anterograde and retrograde transport methods at the light level. Terminals containing phenylethanolamine-N-methyl transferase (PNMT) were mapped using immunocytochemical techniques. PNMT-labeled terminals were present at all levels of thoracic intermediolateral column, in a distribution similar to that of the descending projections from the RVL. We have previously shown, using double label techniques (Ross et al., '81-'83), that many of the spinal projections of the RVL originate from C1 neurons. These data support our suggestion that certain bulbospinal neurons within the RVL, in particular the C1 neurons, are crucial for tonic vasomotor control.

UR - http://www.scopus.com/inward/record.url?scp=0021135776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021135776&partnerID=8YFLogxK

M3 - Article

VL - 228

SP - 168

EP - 185

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 2

ER -