Rosai-Dorfman disease presenting with widespread intracranial and spinal cord involvement

Desmond P. Kidd, Tamas Revesz, Neil R. Miller

Research output: Contribution to journalReview articlepeer-review

Abstract

Rosai-Dorfman disease is associated with a histiocytic infiltration of lymphoid tissue, but may also involve the orbit, nasopharynx, respiratory pathways, gastrointestinal tract, endocrine glands (particularly the thyroid), bone, and skin. Neurologic manifestations are rare, occurring in 4% of one series, and the diagnosis is often not made until pathology is available. Using data from two cases, we present the clinical manifestations, pathology, and treatment, and review the literature regarding the ocular and neurologic manifestations. Finally, we discuss the optimum management of this disorder.

Original languageEnglish (US)
Pages (from-to)1551-1555
Number of pages5
JournalNeurology
Volume67
Issue number9
DOIs
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Clinical Neurology

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