ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

Dong Gil You; V. G. Deepagan; Wooram Um; Sangmin Jeon; Sejin Son; Hyeyoun Chang; Hwa In Yoon; Yong Woo Cho; Maggie Swierczewska; Seulki Lee; Martin G. Pomper; Ick Chan Kwon; Kwangmeyung Kim; Jae Hyung Park

doi:10.1038/srep23200

ROS-generating TiO₂ nanoparticles for non-invasive sonodynamic therapy of cancer

Dong Gil You, V. G. Deepagan, Wooram Um, Sangmin Jeon, Sejin Son, Hyeyoun Chang, Hwa In Yoon, Yong Woo Cho, Maggie Swierczewska, Seulki Lee, Martin G. Pomper, Ick Chan Kwon, Kwangmeyung Kim, Jae Hyung Park

School of Medicine

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed to poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO₂ NP) that can be activated by ultrasound to generate reactive oxygen species (ROS). When administered systemically to mice, HTiO₂ NPs effectively suppressed the growth of superficial tumours after ultrasound treatments. In tumour tissue, the levels of proinflammatory cytokines were elevated several fold and intense vascular damage was observed. Notably, ultrasound treatments with HTiO₂ NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared to animals without ultrasound treatments. This study provides the first demonstration of the feasibility of using HTiO₂ NPs as sensitizers for sonodynamic therapy in vivo.

Original language	English (US)
Article number	23200
Journal	Scientific reports
Volume	6
DOIs	https://doi.org/10.1038/srep23200
State	Published - Mar 21 2016

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title = "ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer",

abstract = "The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed to poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO2 NP) that can be activated by ultrasound to generate reactive oxygen species (ROS). When administered systemically to mice, HTiO2 NPs effectively suppressed the growth of superficial tumours after ultrasound treatments. In tumour tissue, the levels of proinflammatory cytokines were elevated several fold and intense vascular damage was observed. Notably, ultrasound treatments with HTiO2 NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared to animals without ultrasound treatments. This study provides the first demonstration of the feasibility of using HTiO2 NPs as sensitizers for sonodynamic therapy in vivo.",

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AU - You, Dong Gil

AU - Deepagan, V. G.

AU - Um, Wooram

AU - Jeon, Sangmin

AU - Son, Sejin

AU - Chang, Hyeyoun

AU - Yoon, Hwa In

AU - Cho, Yong Woo

AU - Swierczewska, Maggie

AU - Lee, Seulki

AU - Pomper, Martin G.

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Park, Jae Hyung

PY - 2016/3/21

Y1 - 2016/3/21

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ROS-generating TiO₂ nanoparticles for non-invasive sonodynamic therapy of cancer

Abstract

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