Roles of vaccinia virus in the development of new vaccines

Bernard Moss, Thomas R. Fuerst, Charles Flexner, Ambros Hugin

Research output: Contribution to journalArticle

Abstract

Vaccinia virus is an efficient expression vector with broad host range infectivity and large DNA capacity. This vector has been particularly useful for identifying target antigens for humoral and cell-mediated immunity. With increased levels of gene expression, obtained either with stronger vaccinia promoters or through incorporation of the bacteriophage T7 RNA polymerase gene into the vaccinia genome, proteins may be synthesized in mammalian cells for use as subunit vaccines. For use as a live recombinant vaccine, efforts are being made to attenuate vaccinia virus further, either by inactivating genes contributing to virulence or by introducing human lymphokine genes into the vaccinia genome.

Original languageEnglish (US)
Pages (from-to)161-163
Number of pages3
JournalVaccine
Volume6
Issue number2
DOIs
StatePublished - Apr 1988
Externally publishedYes

Keywords

  • Vaccinia virus
  • attenuation
  • recombinant vaccine
  • vector

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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