Roles of Micro-RNAs in Metabolism

Z. Wei; Guang William Wong

doi:10.1016/B978-0-12-378630-2.00078-5

Roles of Micro-RNAs in Metabolism

Z. Wei, Guang William Wong

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Micro-RNAs (miRNAs) are a group of small RNAs that inhibit gene expression by inducing mRNA degradation or repressing mRNA translation. miRNAs represent an ancient and evolutionally conserved mechanism to regulate gene expression in plants and animals. Growing evidence indicated that miRNAs participate in many metabolic processes, including adipocyte differentiation, development of pancreatic islet cells, insulin secretion and signaling, and fatty acid metabolism. Further, certain miRNAs are associated with metabolic dysregulation and thus are candidate targets for therapeutic development. Overall, the studies of miRNA have added a completely new dimension to our understanding of the complex regulatory mechanisms underlying energy homeostasis.

Original language	English (US)
Title of host publication	Encyclopedia of Biological Chemistry
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	191-194
Number of pages	4
ISBN (Electronic)	9780123786319
ISBN (Print)	9780123786302
DOIs	https://doi.org/10.1016/B978-0-12-378630-2.00078-5
State	Published - Feb 15 2013

Keywords

Gene expression
Gene transcription
Glucose metabolism
Insulin secretion
Lipid metabolism
Metabolic diseases
MiRNA
Noncoding RNA
α-Cell biology

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-378630-2.00078-5

Cite this

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title = "Roles of Micro-RNAs in Metabolism",

abstract = "Micro-RNAs (miRNAs) are a group of small RNAs that inhibit gene expression by inducing mRNA degradation or repressing mRNA translation. miRNAs represent an ancient and evolutionally conserved mechanism to regulate gene expression in plants and animals. Growing evidence indicated that miRNAs participate in many metabolic processes, including adipocyte differentiation, development of pancreatic islet cells, insulin secretion and signaling, and fatty acid metabolism. Further, certain miRNAs are associated with metabolic dysregulation and thus are candidate targets for therapeutic development. Overall, the studies of miRNA have added a completely new dimension to our understanding of the complex regulatory mechanisms underlying energy homeostasis.",

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author = "Z. Wei and Wong, {Guang William}",

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AU - Wong, Guang William

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AB - Micro-RNAs (miRNAs) are a group of small RNAs that inhibit gene expression by inducing mRNA degradation or repressing mRNA translation. miRNAs represent an ancient and evolutionally conserved mechanism to regulate gene expression in plants and animals. Growing evidence indicated that miRNAs participate in many metabolic processes, including adipocyte differentiation, development of pancreatic islet cells, insulin secretion and signaling, and fatty acid metabolism. Further, certain miRNAs are associated with metabolic dysregulation and thus are candidate targets for therapeutic development. Overall, the studies of miRNA have added a completely new dimension to our understanding of the complex regulatory mechanisms underlying energy homeostasis.

KW - Gene expression

KW - Gene transcription

KW - Glucose metabolism

KW - Insulin secretion

KW - Lipid metabolism

KW - Metabolic diseases

KW - MiRNA

KW - Noncoding RNA

KW - α-Cell biology

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M3 - Chapter

AN - SCOPUS:85042778917

SN - 9780123786302

SP - 191

EP - 194

BT - Encyclopedia of Biological Chemistry

PB - Elsevier Inc.

ER -

Roles of Micro-RNAs in Metabolism

Abstract

Keywords

ASJC Scopus subject areas

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