Roles of Micro-RNAs in Metabolism

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Micro-RNAs (miRNAs) are a group of small RNAs that inhibit gene expression by inducing mRNA degradation or repressing mRNA translation. miRNAs represent an ancient and evolutionally conserved mechanism to regulate gene expression in plants and animals. Growing evidence indicated that miRNAs participate in many metabolic processes, including adipocyte differentiation, development of pancreatic islet cells, insulin secretion and signaling, and fatty acid metabolism. Further, certain miRNAs are associated with metabolic dysregulation and thus are candidate targets for therapeutic development. Overall, the studies of miRNA have added a completely new dimension to our understanding of the complex regulatory mechanisms underlying energy homeostasis.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages191-194
Number of pages4
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • Gene expression
  • Gene transcription
  • Glucose metabolism
  • Insulin secretion
  • Lipid metabolism
  • Metabolic diseases
  • MiRNA
  • Noncoding RNA
  • α-Cell biology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wei, Z., & Wong, G. W. (2013). Roles of Micro-RNAs in Metabolism. In Encyclopedia of Biological Chemistry: Second Edition (pp. 191-194). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00078-5