Abstract
Infection by the human immunodeficiency virus (HIV) involves a number of important interactions with lipid components in host membranes that regulate binding, fusion, internalization, and viral assembly. Available data suggests that HIV actively modifies the sphingolipid content of cellular membranes to create focal environments that are favorable for infection. In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV.
Original language | English (US) |
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Pages (from-to) | 284-295 |
Number of pages | 12 |
Journal | Journal of Neuroimmune Pharmacology |
Volume | 6 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2011 |
Keywords
- HIV
- Lipid raft
- Sphingolipid
- Therapeutics
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Immunology and Allergy
- Immunology
- Pharmacology