Role of Vitamin D in inflammatory bowel disease

Berkeley N. Limketkai, Gerard E. Mullin, David Limsui, Alyssa M. Parian

Research output: Contribution to journalReview articlepeer-review

Abstract

Vitamin D is a secosteroid hormone that possesses immunomodulatory properties and has been demonstrated to potentially influence inflammatory bowel disease (IBD) pathogenesis and activity. Epidemiologic data have associated vitamin D deficiency with an increased risk of IBD, hospitalizations, surgery, and loss of response to biologic therapy. Conversely, IBD itself can lead to vitamin D deficiency. This bidirectional relationship between vitamin D and IBD suggests the need for monitoring and repletion of vitamin D, as needed, in the IBD patient. This review discusses the role of vitamin D in IBD and provides practical guidance on vitamin D repletion.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalNutrition in Clinical Practice
Volume32
Issue number3
DOIs
StatePublished - Jun 2017

Keywords

  • Cholecalciferol
  • Crohn's disease
  • Ergocalciferol
  • Inflammatory bowel diseases
  • Ulcerative colitis
  • Vitamin D
  • Vitamin D deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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