Role of the T-cell receptor in kidney ischemia-reperfusion injury

V. Savransky, R. R. Molls, M. Burne-Taney, C. C. Chien, Lorraine C Racusen, Hamid Rabb

Research output: Contribution to journalArticle

Abstract

T cells have been demonstrated to modulate ischemia-reperfusion injury (IRI) in kidney, lung, liver and intestine. The underlying mechanisms for T-cell engagement in IRI are unknown. We hypothesized that the T-cell receptor (TCR) plays a role in renal IRI, and examined the effects of TCR alpha/beta (αβ) and gamma/delta (γδ) deficiency on ischemic acute renal failure (ARF). TCR-specific deficiency in specific mice was confirmed by fluorescence-activated cell sorting analysis using monoclonal antibodies (Abs). IRI was induced by bilateral clamping of kidney pedicles for 30 min, followed by reperfusion. Serum creatinine and kidney histopathology were used to assess the severity of experimental ARF. TCR αβ-deficient mice were significantly protected from kidney dysfunction compared to wild-type (WT) littermates after IRI (P

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalKidney International
Volume69
Issue number2
DOIs
StatePublished - Jan 2006

Fingerprint

T-Cell Antigen Receptor
Reperfusion Injury
Kidney
Acute Kidney Injury
Antigen Receptors, T-Cell, alpha-beta
T-Lymphocytes
Constriction
Reperfusion
Intestines
Creatinine
Flow Cytometry
Monoclonal Antibodies
Lung
Liver
Serum

Keywords

  • Acute renal failure
  • Gene knockout mice
  • Ischemia/reperfusion injury
  • T-cell receptor

ASJC Scopus subject areas

  • Nephrology

Cite this

Savransky, V., Molls, R. R., Burne-Taney, M., Chien, C. C., Racusen, L. C., & Rabb, H. (2006). Role of the T-cell receptor in kidney ischemia-reperfusion injury. Kidney International, 69(2), 233-238. https://doi.org/10.1038/sj.ki.5000038

Role of the T-cell receptor in kidney ischemia-reperfusion injury. / Savransky, V.; Molls, R. R.; Burne-Taney, M.; Chien, C. C.; Racusen, Lorraine C; Rabb, Hamid.

In: Kidney International, Vol. 69, No. 2, 01.2006, p. 233-238.

Research output: Contribution to journalArticle

Savransky, V, Molls, RR, Burne-Taney, M, Chien, CC, Racusen, LC & Rabb, H 2006, 'Role of the T-cell receptor in kidney ischemia-reperfusion injury', Kidney International, vol. 69, no. 2, pp. 233-238. https://doi.org/10.1038/sj.ki.5000038
Savransky V, Molls RR, Burne-Taney M, Chien CC, Racusen LC, Rabb H. Role of the T-cell receptor in kidney ischemia-reperfusion injury. Kidney International. 2006 Jan;69(2):233-238. https://doi.org/10.1038/sj.ki.5000038
Savransky, V. ; Molls, R. R. ; Burne-Taney, M. ; Chien, C. C. ; Racusen, Lorraine C ; Rabb, Hamid. / Role of the T-cell receptor in kidney ischemia-reperfusion injury. In: Kidney International. 2006 ; Vol. 69, No. 2. pp. 233-238.
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