Role of the RNA-binding protein HuR in colon carcinogenesis

Isabel López De Silanes, Jinshui Fan, Xiaoling Yang, Alan B. Zonderman, Olga Potapova, Ellen S. Pizer, Myriam Gorospe

Research output: Contribution to journalArticlepeer-review

219 Scopus citations


Immunohistochemical analysis of paired tumor and normal tissue specimens revealed that the expression and cytoplasmic abundance of the RNA-binding protein HuR increased with malignancy, particularly in colon carcinomas. Interventions to modulate HuR expression in human RKO colon cancer cells altered gene expression profiles and identified β-catenin mRNA as a novel HuR target. Subcutaneous injection of HuR-overexpressing RKO cells into nude mice produced significantly larger tumors than those arising from control populations; conversely, RKO cells expressing reduced HuR through small interference RNA- or antisense HuR-based approaches developed significantly more slowly. We propose that HuR-regulated target mRNA expression contributes to colon cancer growth. Our results suggest a pivotal function for HuR in colon carcinogenesis.

Original languageEnglish (US)
Pages (from-to)7146-7154
Number of pages9
Issue number46
StatePublished - Oct 16 2003
Externally publishedYes


  • Carcinogenesis
  • Colon cancer
  • ELAV
  • HuR
  • mRNA turnover

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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