Role of the parasympathetic system in antigen induced bronchospasm

Richard R Rosenthal, Philip S. Norman, W. R. Summer, S. Permutt

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human subjects, sensitive to ragweed, inhaled aerosols of increasing concentrations of ragweed pollen extract in the presence and absence of pretreatment with inhaled atropine. The cumulative dose of antigen required for a 35% decrease in airways conductance was termed PD35. Atropine, 1.2 or 5 mg, increased airways conductance before antigenic challenge but did not alter significantly the PD35 for ragweed extract, although these doses of atropine inhibited airways responses to inhaled methacholine chloride and citric acid. We conclude that the cholinergic nervous system plays a modulating role in bronchomotor tone and responses to irritants, but that parasympathetic reflexes are not invariably a major component of human bronchial responses to inhaled allergen.

Original languageEnglish (US)
Title of host publicationJ.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL.
Pages600-606
Number of pages7
Volume42
Edition4
StatePublished - 1977

Fingerprint

Bronchial Spasm
Atropine
Ambrosia
Antigens
Methacholine Chloride
Irritants
Aerosols
Citric Acid
Allergens
Cholinergic Agents
Nervous System
Reflex

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rosenthal, R. R., Norman, P. S., Summer, W. R., & Permutt, S. (1977). Role of the parasympathetic system in antigen induced bronchospasm. In J.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL. (4 ed., Vol. 42, pp. 600-606)

Role of the parasympathetic system in antigen induced bronchospasm. / Rosenthal, Richard R; Norman, Philip S.; Summer, W. R.; Permutt, S.

J.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL.. Vol. 42 4. ed. 1977. p. 600-606.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rosenthal, RR, Norman, PS, Summer, WR & Permutt, S 1977, Role of the parasympathetic system in antigen induced bronchospasm. in J.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL.. 4 edn, vol. 42, pp. 600-606.
Rosenthal RR, Norman PS, Summer WR, Permutt S. Role of the parasympathetic system in antigen induced bronchospasm. In J.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL.. 4 ed. Vol. 42. 1977. p. 600-606
Rosenthal, Richard R ; Norman, Philip S. ; Summer, W. R. ; Permutt, S. / Role of the parasympathetic system in antigen induced bronchospasm. J.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL.. Vol. 42 4. ed. 1977. pp. 600-606
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