Role of the parasympathetic system in antigen induced bronchospasm

Richard R Rosenthal, Philip S. Norman, W. R. Summer, S. Permutt

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human subjects, sensitive to ragweed, inhaled aerosols of increasing concentrations of ragweed pollen extract in the presence and absence of pretreatment with inhaled atropine. The cumulative dose of antigen required for a 35% decrease in airways conductance was termed PD35. Atropine, 1.2 or 5 mg, increased airways conductance before antigenic challenge but did not alter significantly the PD35 for ragweed extract, although these doses of atropine inhibited airways responses to inhaled methacholine chloride and citric acid. We conclude that the cholinergic nervous system plays a modulating role in bronchomotor tone and responses to irritants, but that parasympathetic reflexes are not invariably a major component of human bronchial responses to inhaled allergen.

Original languageEnglish (US)
Title of host publicationJ.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL.
Pages600-606
Number of pages7
Volume42
Edition4
Publication statusPublished - 1977

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rosenthal, R. R., Norman, P. S., Summer, W. R., & Permutt, S. (1977). Role of the parasympathetic system in antigen induced bronchospasm. In J.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL. (4 ed., Vol. 42, pp. 600-606)