TY - JOUR
T1 - Role of the parasympathetic system in antigen induced bronchospasm
AU - Rosenthal, R. R.
AU - Norman, P. S.
AU - Summer, W. R.
AU - Permutt, S.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - Human subjects, sensitive to ragweed, inhaled aerosols of increasing concentrations of ragweed pollen extract in the presence and absence of pretreatment with inhaled atropine. The cumulative dose of antigen required for a 35% decrease in airways conductance was termed PD35. Atropine, 1.2 or 5 mg, increased airways conductance before antigenic challenge but did not alter significantly the PD35 for ragweed extract, although these doses of atropine inhibited airways responses to inhaled methacholine chloride and citric acid. We conclude that the cholinergic nervous system plays a modulating role in bronchomotor tone and responses to irritants, but that parasympathetic reflexes are not invariably a major component of human bronchial responses to inhaled allergen.
AB - Human subjects, sensitive to ragweed, inhaled aerosols of increasing concentrations of ragweed pollen extract in the presence and absence of pretreatment with inhaled atropine. The cumulative dose of antigen required for a 35% decrease in airways conductance was termed PD35. Atropine, 1.2 or 5 mg, increased airways conductance before antigenic challenge but did not alter significantly the PD35 for ragweed extract, although these doses of atropine inhibited airways responses to inhaled methacholine chloride and citric acid. We conclude that the cholinergic nervous system plays a modulating role in bronchomotor tone and responses to irritants, but that parasympathetic reflexes are not invariably a major component of human bronchial responses to inhaled allergen.
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U2 - 10.1152/jappl.1977.42.4.600
DO - 10.1152/jappl.1977.42.4.600
M3 - Article
C2 - 863822
AN - SCOPUS:0017603089
SN - 0161-7567
VL - 42
SP - 600
EP - 606
JO - J.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL.
JF - J.APPL.PHYSIOL.RESPIR.ENVIRON.EXERCISE PHYSIOL.
IS - 4
ER -