Role of the immune response in recovery from Sindbis virus encephalitis in mice

Research output: Contribution to journalArticle

Abstract

The role of the immune response in recovery from acute encephalitis was studied by using a neuroadapted strain of Sindbis virus. Intracerebral inoculation of this virus caused fatal disease in weanling mice. Passive transfer of homologous immune serum protected mice, but transfer of immune spleen cells and lymph node cells failed to alter mortality. Transfers were made 24 hr after intracerebral infection of the recipient, when central nervous system infection was established. The protective factor in serum was present 7 days after donor infection, was specific for Sindbis virus, and appeared to be IgG; however, the protection did not correlate with virus neutralizing activity.

Original languageEnglish (US)
Pages (from-to)1070-1075
Number of pages6
JournalJournal of Immunology
Volume118
Issue number3
StatePublished - 1977

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Sindbis Virus
Encephalitis
Viruses
Central Nervous System Infections
Infection
Immune Sera
Spleen
Immunoglobulin G
Lymph Nodes
Mortality
Serum
Protective Factors

ASJC Scopus subject areas

  • Immunology

Cite this

Role of the immune response in recovery from Sindbis virus encephalitis in mice. / Griffin, Diane; Johnson, Richard.

In: Journal of Immunology, Vol. 118, No. 3, 1977, p. 1070-1075.

Research output: Contribution to journalArticle

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