TY - JOUR
T1 - Role of the immune response in age-dependent resistance of mice to encephalitis due to sindbis virus
AU - Griffin, Diane E.
N1 - Funding Information:
Received for publication September 8, 1975. This study was supported in part by research grant no. 1-P01-NS-10920 from the U.S. Public Health Service. I thank Mary Macgill and Lisa Werthamer for technical assistance. Dr. Griffin is an investigator of the Howard Hughes Medical Institute. Please address requests for reprints to Dr. Diane E. Griffin, Johns Hopkins University School of Medicine, Traylor 709, Baltimore, Maryland 21205.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1976/4
Y1 - 1976/4
N2 - One-to eight-week-old mice were studied after subcutaneous inoculation of Sindbis virus. Local replication at the site of inoculation, transient viremia, and invasion of the brain were found in mice of all ages, although the quantities of virus were greater in younger mice. Death occurred in 100% of one-week-old mice, 28% of two-week-old mice, and none of the mice four weeks old or older. Pathologic examination of the brains on day 7 after infection revealed a mononuclear inflammatory infiltrate in all mice, with evidence of necrosis in the youngest. Neutralizing antibody was present by day 3 and reached high titers by day 6 in all age groups. Specific stimulation of cells from the draining lymph node by Sindbis virus antigen was also demonstrable by day 6 in all groups. There was no evidence for a primary role of humoral or cellular immune responses in the age-dependent resistance of mice to infection with Sindbis virus.
AB - One-to eight-week-old mice were studied after subcutaneous inoculation of Sindbis virus. Local replication at the site of inoculation, transient viremia, and invasion of the brain were found in mice of all ages, although the quantities of virus were greater in younger mice. Death occurred in 100% of one-week-old mice, 28% of two-week-old mice, and none of the mice four weeks old or older. Pathologic examination of the brains on day 7 after infection revealed a mononuclear inflammatory infiltrate in all mice, with evidence of necrosis in the youngest. Neutralizing antibody was present by day 3 and reached high titers by day 6 in all age groups. Specific stimulation of cells from the draining lymph node by Sindbis virus antigen was also demonstrable by day 6 in all groups. There was no evidence for a primary role of humoral or cellular immune responses in the age-dependent resistance of mice to infection with Sindbis virus.
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U2 - 10.1093/infdis/133.4.456
DO - 10.1093/infdis/133.4.456
M3 - Article
C2 - 1262711
AN - SCOPUS:0017226982
SN - 0022-1899
VL - 133
SP - 456
EP - 464
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -