The results of these experiments in rabbi's indicate that 1 × 106 tumor cells are uniformly fatal when injected intravenously. In contrast, the same dose of tumor cells is not necessarily fatal when injected intralymphatically. Arrest within a lymph node occurred in less than 50 per cent of the animals and the ability to contain tumor within the node decreased with time. A radical neck dissection did not significantly reduce the variable barrier effect which was assumed by small regenerated lymphatic vessels and nodes in the dissected side of the neck or by intact nodes in the contralateral side of the neck.
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