Role of the cervical lymph nodes as a barrier to metastatic tumor

R. Robinson Baker; Sumner Wood; Pham Van Cong; Soo Tae Kim; Vernon T. Tolo

doi:10.1016/0002-9610(69)90207-4

Role of the cervical lymph nodes as a barrier to metastatic tumor

R. Robinson Baker, Sumner Wood, Pham Van Cong, Soo Tae Kim, Vernon T. Tolo

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The results of these experiments in rabbi's indicate that 1 × 10⁶ tumor cells are uniformly fatal when injected intravenously. In contrast, the same dose of tumor cells is not necessarily fatal when injected intralymphatically. Arrest within a lymph node occurred in less than 50 per cent of the animals and the ability to contain tumor within the node decreased with time. A radical neck dissection did not significantly reduce the variable barrier effect which was assumed by small regenerated lymphatic vessels and nodes in the dissected side of the neck or by intact nodes in the contralateral side of the neck.

Original language	English (US)
Pages (from-to)	654-659
Number of pages	6
Journal	The American Journal of Surgery
Volume	118
Issue number	5
DOIs	https://doi.org/10.1016/0002-9610(69)90207-4
State	Published - Nov 1969
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1016/0002-9610(69)90207-4

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title = "Role of the cervical lymph nodes as a barrier to metastatic tumor",

abstract = "The results of these experiments in rabbi's indicate that 1 × 106 tumor cells are uniformly fatal when injected intravenously. In contrast, the same dose of tumor cells is not necessarily fatal when injected intralymphatically. Arrest within a lymph node occurred in less than 50 per cent of the animals and the ability to contain tumor within the node decreased with time. A radical neck dissection did not significantly reduce the variable barrier effect which was assumed by small regenerated lymphatic vessels and nodes in the dissected side of the neck or by intact nodes in the contralateral side of the neck.",

author = "Baker, {R. Robinson} and Sumner Wood and {Van Cong}, Pham and Kim, {Soo Tae} and Tolo, {Vernon T.}",

note = "Funding Information: Hospital, Baltimore, Maryland. by research grants from the (T-395) and the ES. Public Health Funding Information: From the Johns Hopkins This work was supported American Cancer Sdciety Service (C-5319). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1969",

month = nov,

doi = "10.1016/0002-9610(69)90207-4",

language = "English (US)",

volume = "118",

pages = "654--659",

journal = "The American Journal of Surgery",

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T1 - Role of the cervical lymph nodes as a barrier to metastatic tumor

AU - Baker, R. Robinson

AU - Wood, Sumner

AU - Van Cong, Pham

AU - Kim, Soo Tae

AU - Tolo, Vernon T.

N1 - Funding Information: Hospital, Baltimore, Maryland. by research grants from the (T-395) and the ES. Public Health Funding Information: From the Johns Hopkins This work was supported American Cancer Sdciety Service (C-5319). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1969/11

Y1 - 1969/11

N2 - The results of these experiments in rabbi's indicate that 1 × 106 tumor cells are uniformly fatal when injected intravenously. In contrast, the same dose of tumor cells is not necessarily fatal when injected intralymphatically. Arrest within a lymph node occurred in less than 50 per cent of the animals and the ability to contain tumor within the node decreased with time. A radical neck dissection did not significantly reduce the variable barrier effect which was assumed by small regenerated lymphatic vessels and nodes in the dissected side of the neck or by intact nodes in the contralateral side of the neck.

AB - The results of these experiments in rabbi's indicate that 1 × 106 tumor cells are uniformly fatal when injected intravenously. In contrast, the same dose of tumor cells is not necessarily fatal when injected intralymphatically. Arrest within a lymph node occurred in less than 50 per cent of the animals and the ability to contain tumor within the node decreased with time. A radical neck dissection did not significantly reduce the variable barrier effect which was assumed by small regenerated lymphatic vessels and nodes in the dissected side of the neck or by intact nodes in the contralateral side of the neck.

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Role of the cervical lymph nodes as a barrier to metastatic tumor

Abstract

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