Role of the ATP-sensitive potassium current in the development of reentry in a ring model of cardiac tissue. A computer simulation study

J. M. Ferrero, V. Torres, J. Saiz, J. M. Ferrero, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The aim of this work is to study the influence of activation of the ATP-sensitive potassium (KATP) current on vulnerability to reentry during cardiac hypoxia. A detailed mathematical model of this current was introduced into the Luo-Rudy model of the cardiac action potential (AP), and the electrical activity in a ID ring of cardiac tissue was simulated. To reproduce the natural dispersion of the sensitivity of the KATP current to [ATP]i, the half-maximum inhibition constant of the channel was randomized following a Gaussian distribution. Hypoxia was simulated by appropriately reducing [ATP]i and increasing [ADP]i. The simulated hypoxic APs show a significant shortening compared to control APs, and spatial inhomogeneity of action potential duration (APD) is enhanced by inhomogeneous KATP current activation. Moreover, our results show that the hypoxic APD dispersion caused by opening of KATP channels could be enough to elicit reentrant activity.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
Pages605-608
Number of pages4
Volume0
Edition0
StatePublished - 1996

Fingerprint

Reentry
Adenosinetriphosphate
Computer Simulation
Action Potentials
Potassium
Adenosine Triphosphate
Tissue
Computer simulation
Chemical activation
Enzyme inhibition
Administrative data processing
KATP Channels
Normal Distribution
Gaussian distribution
Adenosine Diphosphate
Theoretical Models
Mathematical models
Hypoxia

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Ferrero, J. M., Torres, V., Saiz, J., Ferrero, J. M., & Thakor, N. V. (1996). Role of the ATP-sensitive potassium current in the development of reentry in a ring model of cardiac tissue. A computer simulation study. In Computers in Cardiology (0 ed., Vol. 0, pp. 605-608)

Role of the ATP-sensitive potassium current in the development of reentry in a ring model of cardiac tissue. A computer simulation study. / Ferrero, J. M.; Torres, V.; Saiz, J.; Ferrero, J. M.; Thakor, Nitish V.

Computers in Cardiology. Vol. 0 0. ed. 1996. p. 605-608.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ferrero, JM, Torres, V, Saiz, J, Ferrero, JM & Thakor, NV 1996, Role of the ATP-sensitive potassium current in the development of reentry in a ring model of cardiac tissue. A computer simulation study. in Computers in Cardiology. 0 edn, vol. 0, pp. 605-608.
Ferrero JM, Torres V, Saiz J, Ferrero JM, Thakor NV. Role of the ATP-sensitive potassium current in the development of reentry in a ring model of cardiac tissue. A computer simulation study. In Computers in Cardiology. 0 ed. Vol. 0. 1996. p. 605-608
Ferrero, J. M. ; Torres, V. ; Saiz, J. ; Ferrero, J. M. ; Thakor, Nitish V. / Role of the ATP-sensitive potassium current in the development of reentry in a ring model of cardiac tissue. A computer simulation study. Computers in Cardiology. Vol. 0 0. ed. 1996. pp. 605-608
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