The aim of this work is to study the influence of activation of the ATP-sensitive potassium (KATP) current on vulnerability to reentry during cardiac hypoxia. A detailed mathematical model of this current was introduced into the Luo-Rudy model of the cardiac action potential (AP), and the electrical activity in a ID ring of cardiac tissue was simulated. To reproduce the natural dispersion of the sensitivity of the KATP current to [ATP]i, the half-maximum inhibition constant of the channel was randomized following a Gaussian distribution. Hypoxia was simulated by appropriately reducing [ATP]i and increasing [ADP]i. The simulated hypoxic APs show a significant shortening compared to control APs, and spatial inhomogeneity of action potential duration (APD) is enhanced by inhomogeneous KATP current activation. Moreover, our results show that the hypoxic APD dispersion caused by opening of KATP channels could be enough to elicit reentrant activity.
|Original language||English (US)|
|Number of pages||4|
|Journal||Computers in cardiology|
|State||Published - 1996|
ASJC Scopus subject areas
- Computer Science Applications
- Cardiology and Cardiovascular Medicine