Role of TGF-β signaling in inherited and acquired myopathies

Tyesha N. Burks, Ronald D. Cohn

Research output: Contribution to journalArticle

Abstract

The transforming growth factor-beta (TGF-β) superfamily consists of a variety of cytokines expressed in many different cell types including skeletal muscle. Members of this superfamily that are of particular importance in skeletal muscle are TGF-β1, mitogen-activated protein kinases (MAPKs), and myostatin. These signaling molecules play important roles in skeletal muscle homeostasis and in a variety of inherited and acquired neuromuscular disorders. Expression of these molecules is linked to normal processes in skeletal muscle such as growth, differentiation, regeneration, and stress response. However, chronic elevation of TGF-β1, MAPKs, and myostatin is linked to various features of muscle pathology, including impaired regeneration and atrophy. In this review, we focus on the aberrant signaling of TGF-β in various disorders such as Marfan syndrome, muscular dystrophies, sarcopenia, and critical illness myopathy. We also discuss how the inhibition of several members of the TGF-β signaling pathway has been implicated in ameliorating disease phenotypes, opening up novel therapeutic avenues for a large group of neuromuscular disorders.

Original languageEnglish (US)
Article number19
JournalSkeletal Muscle
Volume1
Issue number1
DOIs
StatePublished - May 4 2011

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Muscular Diseases
Transforming Growth Factor beta
Skeletal Muscle
Myostatin
Mitogen-Activated Protein Kinases
Regeneration
Sarcopenia
Marfan Syndrome
Muscular Dystrophies
Critical Illness
Atrophy
Homeostasis
Pathology
Cytokines
Phenotype
Muscles
Growth

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Orthopedics and Sports Medicine

Cite this

Role of TGF-β signaling in inherited and acquired myopathies. / Burks, Tyesha N.; Cohn, Ronald D.

In: Skeletal Muscle, Vol. 1, No. 1, 19, 04.05.2011.

Research output: Contribution to journalArticle

Burks, Tyesha N. ; Cohn, Ronald D. / Role of TGF-β signaling in inherited and acquired myopathies. In: Skeletal Muscle. 2011 ; Vol. 1, No. 1.
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