Role of supplementary eye field in saccade initiation: Executive, not direct, control

Veit Stuphorn, Joshua W. Brown, Jeffrey D. Schall

Research output: Contribution to journalArticle

Abstract

The goal of this study was to determine whether the activity of neurons in the supplementary eye field (SEF) is sufficient to control saccade initiation in macaque monkeys performing a saccade countermanding (stop signal) task. As previously observed, many neurons in the SEF increase the discharge rate before saccade initiation. However, when saccades are canceled in response to a stop signal, effectively no neurons with presaccadic activity display discharge rate modulation early enough to contribute to saccade cancellation. Moreover, SEF neurons do not exhibit a specific threshold discharge rate that could trigger saccade initiation. Yet, we observed more subtle relations between SEF activation and saccade production. The activity of numerous SEF neurons was correlated with response time and varied with sequential adjustments in response latency. Trials in which monkeys canceled or produced a saccade in a stop signal trial were distinguished by a modest difference in discharge rate of these SEF neurons before stop signal or target presentation. These findings indicate that neurons in the SEF, in contrast to counterparts in the frontal eye field and superior colliculus, do not contribute directly and immediately to the initiation of visually guided saccades. However the SEF may proactively regulate saccade production by biasing the balance between gaze-holding and gazeshifting based on prior performance and anticipated task requirements.

Original languageEnglish (US)
Pages (from-to)801-816
Number of pages16
JournalJournal of Neurophysiology
Volume103
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Saccades
Frontal Lobe
Neurons
Reaction Time
Haplorhini
Social Adjustment
Superior Colliculi
Task Performance and Analysis
Macaca

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Role of supplementary eye field in saccade initiation : Executive, not direct, control. / Stuphorn, Veit; Brown, Joshua W.; Schall, Jeffrey D.

In: Journal of Neurophysiology, Vol. 103, No. 2, 02.2010, p. 801-816.

Research output: Contribution to journalArticle

Stuphorn, Veit ; Brown, Joshua W. ; Schall, Jeffrey D. / Role of supplementary eye field in saccade initiation : Executive, not direct, control. In: Journal of Neurophysiology. 2010 ; Vol. 103, No. 2. pp. 801-816.
@article{f225da1d683b4bb0a274a05267595f23,
title = "Role of supplementary eye field in saccade initiation: Executive, not direct, control",
abstract = "The goal of this study was to determine whether the activity of neurons in the supplementary eye field (SEF) is sufficient to control saccade initiation in macaque monkeys performing a saccade countermanding (stop signal) task. As previously observed, many neurons in the SEF increase the discharge rate before saccade initiation. However, when saccades are canceled in response to a stop signal, effectively no neurons with presaccadic activity display discharge rate modulation early enough to contribute to saccade cancellation. Moreover, SEF neurons do not exhibit a specific threshold discharge rate that could trigger saccade initiation. Yet, we observed more subtle relations between SEF activation and saccade production. The activity of numerous SEF neurons was correlated with response time and varied with sequential adjustments in response latency. Trials in which monkeys canceled or produced a saccade in a stop signal trial were distinguished by a modest difference in discharge rate of these SEF neurons before stop signal or target presentation. These findings indicate that neurons in the SEF, in contrast to counterparts in the frontal eye field and superior colliculus, do not contribute directly and immediately to the initiation of visually guided saccades. However the SEF may proactively regulate saccade production by biasing the balance between gaze-holding and gazeshifting based on prior performance and anticipated task requirements.",
author = "Veit Stuphorn and Brown, {Joshua W.} and Schall, {Jeffrey D.}",
year = "2010",
month = "2",
doi = "10.1152/jn.00221.2009",
language = "English (US)",
volume = "103",
pages = "801--816",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Role of supplementary eye field in saccade initiation

T2 - Executive, not direct, control

AU - Stuphorn, Veit

AU - Brown, Joshua W.

AU - Schall, Jeffrey D.

PY - 2010/2

Y1 - 2010/2

N2 - The goal of this study was to determine whether the activity of neurons in the supplementary eye field (SEF) is sufficient to control saccade initiation in macaque monkeys performing a saccade countermanding (stop signal) task. As previously observed, many neurons in the SEF increase the discharge rate before saccade initiation. However, when saccades are canceled in response to a stop signal, effectively no neurons with presaccadic activity display discharge rate modulation early enough to contribute to saccade cancellation. Moreover, SEF neurons do not exhibit a specific threshold discharge rate that could trigger saccade initiation. Yet, we observed more subtle relations between SEF activation and saccade production. The activity of numerous SEF neurons was correlated with response time and varied with sequential adjustments in response latency. Trials in which monkeys canceled or produced a saccade in a stop signal trial were distinguished by a modest difference in discharge rate of these SEF neurons before stop signal or target presentation. These findings indicate that neurons in the SEF, in contrast to counterparts in the frontal eye field and superior colliculus, do not contribute directly and immediately to the initiation of visually guided saccades. However the SEF may proactively regulate saccade production by biasing the balance between gaze-holding and gazeshifting based on prior performance and anticipated task requirements.

AB - The goal of this study was to determine whether the activity of neurons in the supplementary eye field (SEF) is sufficient to control saccade initiation in macaque monkeys performing a saccade countermanding (stop signal) task. As previously observed, many neurons in the SEF increase the discharge rate before saccade initiation. However, when saccades are canceled in response to a stop signal, effectively no neurons with presaccadic activity display discharge rate modulation early enough to contribute to saccade cancellation. Moreover, SEF neurons do not exhibit a specific threshold discharge rate that could trigger saccade initiation. Yet, we observed more subtle relations between SEF activation and saccade production. The activity of numerous SEF neurons was correlated with response time and varied with sequential adjustments in response latency. Trials in which monkeys canceled or produced a saccade in a stop signal trial were distinguished by a modest difference in discharge rate of these SEF neurons before stop signal or target presentation. These findings indicate that neurons in the SEF, in contrast to counterparts in the frontal eye field and superior colliculus, do not contribute directly and immediately to the initiation of visually guided saccades. However the SEF may proactively regulate saccade production by biasing the balance between gaze-holding and gazeshifting based on prior performance and anticipated task requirements.

UR - http://www.scopus.com/inward/record.url?scp=76649084883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76649084883&partnerID=8YFLogxK

U2 - 10.1152/jn.00221.2009

DO - 10.1152/jn.00221.2009

M3 - Article

C2 - 19939963

AN - SCOPUS:76649084883

VL - 103

SP - 801

EP - 816

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 2

ER -