Role of 68Ga-DOTATATE PET/CT in a Case of SDHB-Related Pterygopalatine Fossa Paraganglioma Successfully Controlled with Octreotide

Abhishek Jha, Mayank Patel, Eva Baker, Melissa K. Gonzales, Alexander Ling, Corina Millo, Marianne Knue, Ali Cahid Civelek, Karel Pacak

Research output: Contribution to journalArticle

Abstract

We describe an unusual case of a 42-year-old female with an unresectable succinate dehydrogenase subunit B (SDHB)-related pterygopalatine fossa paraganglioma. She underwent somatostatin receptor imaging with 68Ga-DOTA(0)-Tyr(3)-octreotate (68Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT), which showed uptake in the above mentioned tumor. Hence, the patient was started on octreotide, a cold somatostatin analog, and responded with tumor stabilization and improvement of clinical symptoms for 36 months since initiation of octreotide therapy. This case demonstrates the role of 68Ga-DOTATATE PET/CT in diagnostic localization and its subsequent role in treatment using cold somatostatin analog as a potential choice of therapy in the management of paraganglioma in an unusual location with limited therapeutic options.

Original languageEnglish (US)
Pages (from-to)48-52
Number of pages5
JournalNuclear Medicine and Molecular Imaging
Volume54
Issue number1
DOIs
StatePublished - Feb 1 2020

Keywords

  • Ga-DOTATATE PET/CT
  • Lu-DOTATATE
  • Octreotide
  • PRRT
  • Paraganglioma
  • SDHB
  • SSTR
  • Somatostatin analog

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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