Role of sublingual nitroglycerin in patients with acute myocardial infarction

C. E. Delgado, B. Pitt, D. R. Taylor, Myron Weisfeldt, D. T. Kelly

Research output: Contribution to journalArticle

Abstract

14 Patients with acute myocardial infarction were given 0.3 mg sublingual nitroglycerin within the first 12 hr of their acute myocardial infarction. 5 Min after sublingual nitroglycerin mean arterial pressure fell 9 mmHg (1.2 kPa) and remained significantly reduced for 30 min. Pulmonary capillary wedge pressure fell from a mean control value of 17 to 12 mmHg (2.3 to 1.6 kPa) and also remained reduced for 30 min. Heart rate was significantly raised and stroke work index reduced at 5 min. Patients with a stroke work index of greater than 55 g m per m 2 b.s.a. responded to nitroglycerin with a fall in both pulmonary capillary wedge pressure and stroke work index while in those with a stroke index of less than 55 9 m per m 2 b.s.a. stroke work index did not fall concomitantly with the fall in pulmonary capillary wedge pressure. In one patient, nitroglycerin led to a precipitous fall in arterial pressure and recurrence of chest pain.

Original languageEnglish (US)
Pages (from-to)392-396
Number of pages5
JournalBritish Heart Journal
Volume37
Issue number4
StatePublished - 1975
Externally publishedYes

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Nitroglycerin
Stroke
Myocardial Infarction
Pulmonary Wedge Pressure
Arterial Pressure
Chest Pain
Heart Rate
Recurrence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Delgado, C. E., Pitt, B., Taylor, D. R., Weisfeldt, M., & Kelly, D. T. (1975). Role of sublingual nitroglycerin in patients with acute myocardial infarction. British Heart Journal, 37(4), 392-396.

Role of sublingual nitroglycerin in patients with acute myocardial infarction. / Delgado, C. E.; Pitt, B.; Taylor, D. R.; Weisfeldt, Myron; Kelly, D. T.

In: British Heart Journal, Vol. 37, No. 4, 1975, p. 392-396.

Research output: Contribution to journalArticle

Delgado, CE, Pitt, B, Taylor, DR, Weisfeldt, M & Kelly, DT 1975, 'Role of sublingual nitroglycerin in patients with acute myocardial infarction', British Heart Journal, vol. 37, no. 4, pp. 392-396.
Delgado, C. E. ; Pitt, B. ; Taylor, D. R. ; Weisfeldt, Myron ; Kelly, D. T. / Role of sublingual nitroglycerin in patients with acute myocardial infarction. In: British Heart Journal. 1975 ; Vol. 37, No. 4. pp. 392-396.
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