Role of stress response sigma factor SigG in Mycobactenum tuberculosis

Jong Hee Lee, Deborah E. Geiman, William R. Bishai

Research output: Contribution to journalArticlepeer-review

Abstract

The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N15-18-CGANCA. A ΔsigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)1128-1133
Number of pages6
JournalJournal of bacteriology
Volume190
Issue number3
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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