Role of stress response sigma factor SigG in Mycobactenum tuberculosis

Jong Hee Lee; Deborah E. Geiman; William R. Bishai

doi:10.1128/JB.00511-07

Role of stress response sigma factor SigG in Mycobactenum tuberculosis

Jong Hee Lee, Deborah E. Geiman, William R. Bishai

Johns Hopkins Hospital

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N_15-18-CGANCA. A ΔsigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.

Original language	English (US)
Pages (from-to)	1128-1133
Number of pages	6
Journal	Journal of bacteriology
Volume	190
Issue number	3
DOIs	https://doi.org/10.1128/JB.00511-07
State	Published - Feb 2008

ASJC Scopus subject areas

Microbiology
Molecular Biology

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abstract = "The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N15-18-CGANCA. A ΔsigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.",

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AB - The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N15-18-CGANCA. A ΔsigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.

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Role of stress response sigma factor SigG in Mycobactenum tuberculosis

Abstract

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